PV-DPD-19 |
Katalog-Nr.GC78907
One-Click Copy Product Info
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PV-DPD-19 is an autoinducer-2 ( AI-2 ) quorum sensing inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3112321-20-4
Sample solution is provided at 25 µL, 10mM.
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In Vivo, PV-DPD-19 (1-200 μM; injected into the proleg using a microsyringe; single dose) shows no visible acute toxicity to Galleria mellonella (greater wax moth) larvae even at concentrations up to 200 μM, with the survival rate maintained at ≥97% within 72 h[1].
In Vitro, PV-DPD-19 inhibits biofilm formation by *Pseudomonas aeruginosa* (MBIC50 = 27 μg/mL) and *Staphylococcus aureus* (MBIC50 = 35 μg/mL)[1]. PV-DPD-19 significantly reduces the adhesion rate of *Staphylococcus aureus* to human A549 epithelial cells by approximately 30%[1]. PV-DPD-19 (2 mM; overnight, 8 h) significantly reduces AI-2 production in *Staphylococcus aureus* SH1000 as determined by the *Vibrio harveyi* bioluminescence assay[1]. PV-DPD-19 (20-40 μM; 16 h) reduces pyocyanin production in *Pseudomonas aeruginosa* PAO1 in a dose-dependent manner[1]. PV-DPD-19 (3.12-200 μM; 24 h) shows no cytotoxicity against epithelial cell line A549[1].
References:
[1]. Pellegrini A, et al.. Targeting Autoinducer-2 Quorum Sensing: Novel Inhibitors Attenuate Virulence in Staphylococcus aureus and Pseudomonas aeruginosa[J]. ACS Omega, 2026.
| Cas No. | 3112321-20-4 | SDF | |
| Formula | C15H19NO5 | M.Wt | 293.32 |
| Löslichkeit | Storage | Store at -20°C | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.4092 mL | 17.0462 mL | 34.0925 mL |
| 5 mM | 681.8 μL | 3.4092 mL | 6.8185 mL |
| 10 mM | 340.9 μL | 1.7046 mL | 3.4092 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)