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Rac GTPase fragment (Synonyms: H2N-Val-Phe-Asp-Glu-Ala-Ile-Arg-Ala-Val-OH )

Katalog-Nr.GP10032

Fragment of small signaling G proteins

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Rac GTPase fragment Chemische Struktur

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1mg
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10mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Rac GTPase fragment, (C46H74N12O14), a peptide with the sequence H2N-Val-Phe-Asp-Glu-Ala-Ile-Arg-Ala-Val-OH, MW= 1019.15. Rac is a subfamily of the Rho family of GTPases, small signaling G proteins (more specifically a GTPase). Rac1 is thought to play a significant role in the development of various cancers, including melanoma 1 and non-small cell lung cancer2. Rac1 is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases Rac1 is a pleiotropic regulator of many cellular processes, including the cell cycle, cell-cell adhesion, motility (through the actin network), and of epithelial differentiation 3.

References:
1. Hodis, E; Watson, IR; Kryukov, GV; Arold, ST; Imielinski, M; Theurillat, JP; Nickerson, E; Auclair, D; Li, L; Place, C; Dicara, D; Ramos, AH; Lawrence, MS; Cibulskis, K; Sivachenko, A; Voet, D; Saksena, G; Stransky, N; Onofrio, RC; Winckler, W; Ardlie, K; Wagle, N; Wargo, J; Chong, K; Morton, DL; Stemke-Hale, K; Chen, G; Noble, M; Meyerson, M; Ladbury, JE; Davies, MA; Gershenwald, JE; Wagner, SN; Hoon, DS; Schadendorf, D; Lander, ES; Gabriel, SB; Getz, G; Garraway, LA; Chin, L (2012 Jul 18). "A landscape of driver mutations in melanoma.". Cell.
2. Stallings-Mann, M. L.; Waldmann, J.; Zhang, Y.; Miller, E.; Gauthier, M. L.; Visscher, D. W.; Downey, G. P.; Radisky, E. S. et al. (2012). "Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression". Science Translational Medicine 4 (142): 142ra95-142ra95.
3. Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522-9.

Chemical Properties

Cas No. SDF
Überlieferungen H2N-Val-Phe-Asp-Glu-Ala-Ile-Arg-Ala-Val-OH
Canonical SMILES NC(C(C)C)C(NC(CC1=CC=CC=C1)C(NC(CC(O)=O)C(NC(CCC(O)=O)C(NC(C)C(NC(C(NC(CCCNC(N)=N)C(NC(C)C(NC(C(C)C)C(O)=O)=O)=O)=O)C(C)CC)=O)=O)=O)=O)=O
Formula C46H74N12O14 M.Wt 1019.15
Löslichkeit ≥101.9mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 0.9812 mL 4.906 mL 9.8121 mL
5 mM 0.1962 mL 0.9812 mL 1.9624 mL
10 mM 0.0981 mL 0.4906 mL 0.9812 mL
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