KEAP1-Nrf2

The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

Products Related to KEAP1-Nrf2(81)

GN10415 Astilbin
CAS: 29838-67-3
Purity: >97.00%
GN10470 Eriodictyol
CAS: 552-58-9
Purity: >99.50%
GN10491 Mangiferin
CAS: 4773-96-0
Purity: >99.50%
GN10531 Dimethylfraxetin
CAS: 6035-49-0
Purity: >99.50%
GN10629 5,7-dihydroxychromone
CAS: 31721-94-5
Purity: >99.00%
5,7-dihydroxychromone, a flavonoid decomposition product from peanut shells, inhibits the radicle elongation of velvetleaf, corn, peanut, and wheat.
GN10654 (+)-Corynoline
CAS: 18797-79-0
Purity: >98.00%
GN10741 Garcinone D
CAS: 107390-08-9
Purity: >98.00%
GC16590 Dimethyl Fumarate
CAS: 624-49-7
Purity: >97.00%
Dimethylfumarat (DMF) ist ein oral aktiver und in das Gehirn eindringender Nrf2-Aktivator und induziert eine Hochregulierung der antioxidativen Genexpression.
GC13693 Omaveloxolone (RTA-408)
CAS: 1474034-05-3
Purity: >98.00%
Omaveloxolon (RTA-408) (RTA 408) ist ein antioxidativer EntzÜndungsmodulator (AIM), der Nrf2 aktiviert und Stickstoffmonoxid (NO) unterdrÜckt.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GN10415	Astilbin	29838-67-3	>97.00%
GN10470	Eriodictyol	552-58-9	>99.50%
GN10491	Mangiferin	4773-96-0	>99.50%
GN10531	Dimethylfraxetin	6035-49-0	>99.50%
GN10629	5,7-dihydroxychromone	31721-94-5	>99.00%
GN10629	5,7-dihydroxychromone, a flavonoid decomposition product from peanut shells, inhibits the radicle elongation of velvetleaf, corn, peanut, and wheat.
GN10654	(+)-Corynoline	18797-79-0	>98.00%
GN10741	Garcinone D	107390-08-9	>98.00%
GC16590	Dimethyl Fumarate	624-49-7	>97.00%
GC16590	Dimethylfumarat (DMF) ist ein oral aktiver und in das Gehirn eindringender Nrf2-Aktivator und induziert eine Hochregulierung der antioxidativen Genexpression.
GC13693	Omaveloxolone (RTA-408)	1474034-05-3	>98.00%
GC13693	Omaveloxolon (RTA-408) (RTA 408) ist ein antioxidativer EntzÜndungsmodulator (AIM), der Nrf2 aktiviert und Stickstoffmonoxid (NO) unterdrÜckt.