Cardiovascular

PGPC is an oxidized phospholipid that can be formed under conditions of oxidative stress.

Phenylephrine glucuronide is a metabolite of the α1A-adrenergic receptor agonist phenylephrine .

Phenylephrine-3-O-sulfate is metabolite of the α1A-adrenergic receptor agonist phenylephrine formed via sulfation.

Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina.

PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM).

Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic.

Propranolol β-D-glucuronide is a major metabolite of propranolol.

PGI3 is synthesized from EPA by COX and PGI synthase.

Protopine is an alkaloid found in Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae, and Papaveraceae with diverse biological activities.

Quinidine N-oxide is a pharmacologically inactive quinidine metabolite.

R-(-)-Flecainide is the (R) enantiomer of the antiarrhythmic agent flecainide.

rac-7-hydroxy Propranolol (hydrochloride) is a ring-hydroxylated isomer and metabolite of propranolol that is an antagonist at β-adrenergic receptors (0.95 potency relative to propranolol).

S1QEL1.1 is a small molecule that suppresses superoxide production during reverse electron transport through the IQ site of the mitochondrial respiratory complex I (IC50 = 70 nM) without affecting oxidative phosphorylation.

Levalbuterol ((R)-Albuterol) Hydrochlorid ist ein kurzwirksamer β2-adrenerger Rezeptoragonist und das aktive (R)-Enantiomer von Salbutamol.

Hydrogen sulfide (H2S) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals.

Telmisartan acyl-β-D-glucuronide is a major metabolite of the angiotensin II receptor antagonist telmisartan.

Terpendol C, produziert von Albophoma yamanashiensis, zeigt eine starke inhibitorische AktivitÄt gegen Acyl-CoA: Cholesterin-Acyltransferase (ACAT).

Thrombin receptor agonist peptide (TRAP-14) is a 14-amino acid peptide agonist of the α-thrombin receptor.

Thrombin receptor peptide ligand is antagonist of the thrombin receptor (EC50s = 16-33 μM to inhibit platelet aggregation in vitro).

TIQ-A ist ein potenter TNKS (Poly-ART, PARP)-Inhibitor mit einem IC50-Wert von 24 nM fÜr TNKS2.

Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and cholesterol accumulation in vascular tissues.

TRAP-6 peptide is a hexapeptide corresponding to residues 42-47 of protease-activated receptor 1 (PAR1).

Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 μM), which is an enzyme involved in the biosynthesis of cholesterol.

Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide.