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PARP

PARP Inhibitors

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Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

Products Related to PARP(162)

  • GC73633 structure
    GC73633TNKS-2-IN-2
    CAS: 2719726-91-5
    Purity: >99.00%

    TNKS-2-IN-2 ist ein potenter und selektiver TNKS2-Inhibitor mit einem IC50 von 22 nM.

  • GC73639 structure
    GC73639PARP7-IN-16
    CAS: 2435657-10-4
    Purity: >95.00%

    PARP7-IN-16 (Verbindung 36) ist ein potenter, selektiver und oral aktiver Inhibitor von PARP-1/2/7, mit IC50s von 0.94, 0.87 und 0.21 nM, jeweils.

  • GC73640 structure
    GC73640PARP7-IN-16 free base
    CAS: 2136325-05-6

    PARP7-IN-16 free base ist die freie Basisform von PARP7-IN-16.

  • GC73642 structure
    GC73642ALK-IN-26
    CAS: 2447607-85-2
    Purity: >99.00%

    ALK-IN-26 ist ein ALK-Inhibitor mit einem IC50-Wert von 7,0 μM für ALK-Tyrosinkinase.

  • GC73760 structure
    GC73760Trilexium
    CAS: 1983180-82-0
    Purity: >99.00%

    Trilexium (TRX-E-009-1) ist eine dritte Generation von Benzopyran, die strukturell mit TRX-E-002-1 verwandt ist.

  • GC73919 structure
    GC73919AZD-9574-acid
    CAS: 2923687-90-3

    AZD-9574-acid (70D), ein PPAR-1 Inhibitor, kann für die Synthese von PROTAC (CAS 2923686-70-6) verwendet werden.

  • GC73943 structure
    GC73943Polθ/PARP-IN-1
    Purity: >99.00%

    Polθ/PARP-IN-1 (Verbindung 25d) ist ein potenter dualer DNA-Polymerase-Theta (Polθ) und PARP-Inhibitor mit IC50-Werten von 45,6, 5,4 nM.

  • GC74078 structure
    GC74078PARP1-IN-29
    CAS: 1567375-93-2

    PARP1-IN-29 ist ein oral aktiver PARP-1-Inhibitor mit einem IC50-Wert von 6,3 nM.

  • GC78810 structure
    GC78810Anisomelic acid
    CAS: 59632-76-7
    Purity: >98.00%

    Anisomelic acid is a human papillomavirus HPV16 E6 and HPV E7 depletor.

  • GC78957 structure
    GC78957(2S,3R,4S)-ASX-173
    CAS: 2748800-07-7
    Purity: >99.00%

    (2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173.

  • GC78958 structure
    GC78958TMLB-C16
    CAS: 2923531-50-2
    Purity: >99.00%

    TMLB-C16 is a potent and orally active B3GAT3 inhibitor with a K D of 3.962 μM.

  • GC78961 structure
    GC78961GPS167
    CAS: 3034312-19-8
    Purity: >98.00%

    GPS167 is a CLK kinase inhibitor that potently and selectively inhibits recombinant human CLK1, CLK2 and CLK4.

  • GC79050 structure
    GC79050OUL312
    Purity: >99.00%

    OUL312 is a potent PARP10 inhibitor ( IC 50 = 20 nM), showing more than 75-fold greater selectivity for PARP15 ( IC 50 = 1500 nM).

  • GC79056 structure
    GC79056KMR-206
    CAS: 2992741-10-1
    Purity: >99.50%

    KMR-206 is a PARP7 inhibitor with an IC 50 of 13.7 nM.

  • GC79058 structure
    GC79058PARP1/NAMPT-IN-1
    CAS: 3084810-86-3
    Purity: >98.00%

    PARP1/NAMPT-IN-1 is a potent and dual PARP1 and NAMPT inhibitor with IC 50 values of 1.2 nM and 6.7 nM, respectively.

  • GC79060 structure
    GC79060A-620223
    CAS: 272769-49-0
    Purity: >96.00%

    A-620223 is a PARP-1 inhibitor with a K i of 8 nM against PARP-1 and EC 50 of 3 nM in a whole cell assay.

  • GC79061 structure
    GC79061PARP1-IN-56
    CAS: 1574367-80-8
    Purity: >99.00%

    PARP1-IN-56 (Compound RCY) is an I-labeled poly(ADP−ribose) polymerase ( PARP1 ) inhibitor.

  • GC79062 structure
    GC79062PCIP-1
    Purity: >98.50%

    PCIP-1 is a PARP2 inhibitor.

  • GC79063 structure
    GC79063TNKS-IN-1
    CAS: 59455-93-5
    Purity: >99.50%

    TNKS-IN-1 is a selective and potent tankyrase ( TNKS1 / TNKS2 ) inhibitor with IC 50 values of 7.9 nM and 8.7 nM.

  • GC79072 structure
    GC79072MS6076
    Purity: >98.00%

    MS6076 is a mitochondrial protease ClpP agonist.

  • GC79451 structure
    GC79451JP-11646
    CAS: 1902983-63-4
    Purity: >98.50%

    JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 ( IC 50 = 0.5 nM).

  • GC79577 structure
    GC79577PFKFB4-IN-1
    CAS: 2664831-55-2
    Purity: >99.50%

    PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor ( IC 50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels.

  • GC79871 structure
    GC79871CHNQD-00824
    CAS: 2222643-74-3
    Purity: >98.00%

    CHNQD-00824 is a Terphenyllin derivative with potent anticancer effect.

  • GC80334 structure
    GC80334Rucaparib-d 3
    CAS: 2271225-13-7
    Purity: >98.00%

    Rucaparib -d 3 (AG014699-d 3 ) is the deuterated -labeled Rucaparib.