Obesity, Appetite Control & Diabetes

Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).

GLP-1 (7-36) amide is a peptide hormone released from intestinal L-cells upon nutrient consumption.

Glucagon-like peptide-1 (GLP-1) (7-37) is an endogenous incretin hormone and truncated form of GLP-1 (1-37) that is produced via cleavage of preproglucagon in the pancreas and intestine.

Glucagon-like peptide-2 (GLP-2) is an endogenous peptide hormone formed in L cells of the small and large intestine by cleavage of proglucagon in response to nutrient ingestion.

An inactive control for glucagon receptor antagonist I

Glucocerebrosides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase.

Glyburide is a sulfonylurea and an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.3 nM).

Eine glycin-konjugierte Form der sekundären Gallensäure Lithocholsäure.

Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid.

GW9578 ist ein Subtyp-selektiver PPARα-Agonist (EC50s von 5 und 50 nM fÜr murines und humanes PPAR-α) mit starker lipidsenkender AktivitÄt.

Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μ ;M, 1.650 μM fÜr ROCK2 bzw. PKA, PKC, PKG. HA-1077 (Hydrochlorid) ist auch ein potenter Ca2+-Kanalantagonist und Vasodilatator.

Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis.

Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit.

Lithocholic acid 3-sulfate is a metabolite of the secondary bile acid lithocholic acid.

MHY908 ist ein potenter dualer Agonist von PPARα und PPARγ.

ML-262 is an inhibitor of hepatic lipid droplet formation (IC50 = 6.4 nM in murine AML-12 cells), which is associated with non-alcoholic fatty liver disease.

MLS-0322825 Cmpd 23 ist ein selektiver Inhibitor der niedermolekularen Proteintyrosinphosphatase (LMPTP) mit einem IC50-Wert von 0,8 μM LMPTP-A.

Agmatine is a natural polyamine formed by the enzymatic decarboxylation of arginine.

ND-336 ist ein selektiver Inhibitor der Matrix-Metalloproteinase (MMP)-2, MMP-9 und MMP-14 mit Kis-Werten von 85, 150 bzw. 120 nM.

Neuromedin S is a neuropeptide expressed in brain.

N-Oleoyl Leucine is a fatty acid–amino acid conjugate (FAAA) that belongs to the family of N-acyl amino acids.

O-7460 ist ein potenter und selektiver DAGLα-Inhibitor mit einem IC50-Wert von 0,69 μM.

Obestatin is a 23-amino acid peptide hormone that is formed by cleavage of the ghrelin and obestatin prepropeptide.

Orlistat degradation product is a degradation product of the digestive lipase inhibitor orlistat.