O-7460 |
| Katalog-Nr.GC44481 |
O-7460 ist ein potenter und selektiver DAGLα-Inhibitor mit einem IC50-Wert von 0,69 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1572051-31-0
Sample solution is provided at 25 µL, 10mM.
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In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM). It demonstrates much weaker inhibition towards human monoacylglycerol lipase and rat brain fatty acid amide hydrolase (IC50s > 10 µM) and does not bind to CB1 or CB2 cannabinoid receptors (Kis > 10 µM). At 0-12 mg/kg, i.p. in mice, O-7460 was reported to dose-dependently inhibit high-fat diet intake and reduce body weight.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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