SARM1-IN-9 (Compound MY-13B) is a stereoselective SARM1 inhibitor. SARM1-IN-9 is applicable to research related to axon degeneration-dependent neurological diseases [1].
In Vitro, SARM1-IN-9 (20 μM; 1 h) binds stereoselectively to recombinantly expressed wild-type SARM1 in HEK293T cells[1].
References:
[1]. Feldman HC, et al. Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain. Proc Natl Acad Sci U S A. 2022;119(35):e2208457119.
In Vitro, SARM1-IN-9 (20 μM; 1 h) binds stereoselectively to recombinantly expressed wild-type SARM1 in HEK293T cells[1].
References:
[1]. Feldman HC, et al. Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain. Proc Natl Acad Sci U S A. 2022;119(35):e2208457119.