Tubermycin B (Synonyms: NSC 15851, PCA, Phenazine-1-carboxylate, Phenazinecarboxylic Acid, Shenqinmycin)

Tubermycin B is a bacterial metabolite that has been found in Pseudomonas and has antifungal and fungicidal activities.^1,2 It is active against A. flavus, C. albicans, and T. rubrum (MICs = 64, 8, and 4 µg/ml, respectively), as well as the plant pathogenic fungi F. oxysporum and R. solani (MICs = 125 and 32 µg/ml, respectively).¹ Tubermycin B (10-500 µg/ml) prevents the development of foliar anthracnose lesions in cucumber plants infected with the plant pathogenic fungus C. orbiculare.² Formulations containing tubermycin B have been used as fungicides in agriculture.

1.Gorantla, J.N., Kumar, S.N., Nisha, G.V., et al.Purification and characterization of antifungal phenazines from a fluorescent Pseudomonas strain FPO4 against medically important fungiJ. Mycol. Med.24(3)185-192(2014) 2.Lee, J.Y., Moon, S.S., and Hwang, B.K.Isolation and in vitro and in vivo activity against Phytophthora capsici and Colletotrichum orbiculare of phenazine-1-carboxylic acid from Pseudomonas aeruginosa strain GC-B26Pest. Manag. Sci.59(8)872-882(2003)