Dichlorvos (Synonyms: DDVP, Dichlorovinyl Dimethyl Phosphate, NSC 6738) |
Catalog No.GC47211
One-Click Copy Product Info
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An organophosphate insecticide
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 62-73-7
Sample solution is provided at 25 µL, 10mM.
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Dichlorvos is an organophosphate insecticide and inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 269 and 44 nM, respectively).1 It also binds to the M2 muscarinic receptor in rat heart homogenates.2 Dichlorvos is lethal to 4-week old German cockroach (B. germanica) nymphs (LD50 = 0.108 μg per insect) and silkworms (B. mori) in third instar (LC50 = 6.63 mg/L) after 24 hours.3,4 It is lethal to zebrafish (D. rerio) embryos (LC50 = 39.75 mg/L after 24 hours) and decreases swimming activity of larvae 6 days after fertilization when administered at a concentration of 25 mg/L in tank water.5 Dichlorvos (150 ppm for 80 weeks) also increases the incidence of benign and malignant neoplasms in male rats from 47 to 88% as compared to controls.6
1.Petroianu, G.A., Schmitt, A., Arafat, K., et al.Weak inhibitors protect cholinesterases from stronger inhibitors (dichlorvos): In vitro effect of tiaprideInt. J. Toxicol.24(2)79-86(2005) 2.Silveira, C.L., Eldefrawi, A.T., and Eldefrawi, M.E.Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterasesToxicol. Appl. Pharmacol.103(3)474-481(1990) 3.Qian, K., Wei, X., Zeng, X., et al.Stage-dependent tolerance of the German cockroach, Blattella germanica for dichlorvos and propoxuJ. Insect Sci.10(1)201(2010) 4.Zhang, Z.-Y., Wang, D.-L., Chi, Z.-J., et al.Acute toxicity of organophosphorus and pyrethroid insecticides to Bombyx moriJ. Econ. Entomol.101(2)360-364(2008) 5.Si?man, T.Dichlorvos-induced developmental toxicity in zebrafishToxicol. Ind. Health26(9)567-573(2010) 6.Reuber, M.D.Carcinogenicity of dichlorvosClin. Toxicol.18(1)47-84(1981)
| Cas No. | 62-73-7 | SDF | |
| Synonyms | DDVP, Dichlorovinyl Dimethyl Phosphate, NSC 6738 | ||
| Canonical SMILES | Cl/C(Cl)=C/OP(OC)(OC)=O | ||
| Formula | C4H7Cl2O4P | M.Wt | 221 |
| Solubility | Chloroform: soluble,Ethyl Acetate: soluble,Methanol: soluble,Water: soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.5249 mL | 22.6244 mL | 45.2489 mL |
| 5 mM | 905 μL | 4.5249 mL | 9.0498 mL |
| 10 mM | 452.5 μL | 2.2624 mL | 4.5249 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solution in methanol
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)