Dihydroorotate Dehydrogenase

Dihydroorotate dehydrogenase (DHODH) is the fourth enzyme in the de novo pyrimidine biosynthesis pathway, serving as the catalyst to oxidize the dihydroorotate to orotic acid in the biosynthesis of uridine monophosphate (UMP). DHODH is a known target for autoimmune diseases as well as an important target for malaria.

Based on localization and electron acceptor, DHODHs have classified into two families: Family 1 members are soluble proteins localized to the cytosol, while family 2 members are membrane proteins localized to the inner mitochondrial membrane. Family 1 is further subdivided into family 1A and family 1B, which use fumarate and NAD+ (respectively) as electron acceptors. Family 2 DHODH enzymes use respiratory quinones as electron acceptors.

Products Related to Dihydroorotate Dehydrogenase(15)

GC39234 DHODH-IN-2
CAS: 1644156-80-8
Purity: >99.50%
GC39374 DHODH-IN-5
CAS: 1644156-56-8
Purity: >99.50%
GC39632 Laflunimus
CAS: 147076-36-6
Purity: >99.00%
Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726.
GC60763 DHODH-IN-11
CAS: 1263303-95-2
Purity: >99.50%
DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
GC62336 CHIKV-IN-2
CAS: 2361289-44-1
Purity: >98.00%
CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability.
GC62470 AG-636
CAS: 1623416-31-8
Purity: >98.00%
AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. AG-636 has strong anticancer effects.
GC63418 DHODH-IN-17
CAS: 16344-26-6
Purity: >99.50%
DHODH-IN-17, a 2-anilino nicotinic acid, is a human DHODH inhibitor (IC50=0.40 μM). DHODH-IN-17 can be used for theresearch of acute myeloid leukemia (AML).
GC63533 DSM502
CAS: 2426616-55-7
Purity: >99.50%
DSM502 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor.
GC63547 DHODH-IN-16
CAS: 2511248-11-4
Purity: >99.50%
DHODH-IN-16 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH.
GC64074 DSM705 hydrochloride
CAS: 2989908-08-7
Purity: >99.00%
DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor.
GC65335 PTC299
CAS: 1256565-36-2
Purity: >99.00%
PTC299 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH). PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression. PTC299 can be useful for the research of hematologic malignancies.
GC68972 DHODH-IN-23
CAS: 1346705-53-0
Purity: >99.00%
DHODH-IN-23 (Compound A) is an orally active DHODH inhibitor that can be used for cancer research.
GC71093 hDHODH-IN-13
CAS: 3032611-13-2
Purity: >99.00%
hDHODH-IN-13 (compound w2) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 value of 173.4 nM. hDHODH-IN-13 can be used in the research of IBD.
GC79566 DHODH-IN-31
Purity: >99.50%
DHODH-IN-31 is a human dihydroorotate dehydrogenase ( DHODH ) inhibitor with an IC 50 of 0.59 μM.
GC79592 (S)-DSM1465
CAS: 3109381-05-4
Purity: >99.50%
(S)-DSM1465 is a Plasmodium dihydroorotate dehydrogenase ( DHODH ) inhibitor.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC39234	DHODH-IN-2	1644156-80-8	>99.50%
GC39374	DHODH-IN-5	1644156-56-8	>99.50%
GC39632	Laflunimus	147076-36-6	>99.00%
GC39632	Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726.
GC60763	DHODH-IN-11	1263303-95-2	>99.50%
GC60763	DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
GC62336	CHIKV-IN-2	2361289-44-1	>98.00%
GC62336	CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability.
GC62470	AG-636	1623416-31-8	>98.00%
GC62470	AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. AG-636 has strong anticancer effects.
GC63418	DHODH-IN-17	16344-26-6	>99.50%
GC63418	DHODH-IN-17, a 2-anilino nicotinic acid, is a human DHODH inhibitor (IC50=0.40 μM). DHODH-IN-17 can be used for theresearch of acute myeloid leukemia (AML).
GC63533	DSM502	2426616-55-7	>99.50%
GC63533	DSM502 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor.
GC63547	DHODH-IN-16	2511248-11-4	>99.50%
GC63547	DHODH-IN-16 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH.
GC64074	DSM705 hydrochloride	2989908-08-7	>99.00%
GC64074	DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor.
GC65335	PTC299	1256565-36-2	>99.00%
GC65335	PTC299 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH). PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression. PTC299 can be useful for the research of hematologic malignancies.
GC68972	DHODH-IN-23	1346705-53-0	>99.00%
GC68972	DHODH-IN-23 (Compound A) is an orally active DHODH inhibitor that can be used for cancer research.
GC71093	hDHODH-IN-13	3032611-13-2	>99.00%
GC71093	hDHODH-IN-13 (compound w2) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 value of 173.4 nM. hDHODH-IN-13 can be used in the research of IBD.
GC79566	DHODH-IN-31	-	>99.50%
GC79566	DHODH-IN-31 is a human dihydroorotate dehydrogenase ( DHODH ) inhibitor with an IC 50 of 0.59 μM.
GC79592	(S)-DSM1465	3109381-05-4	>99.50%
GC79592	(S)-DSM1465 is a Plasmodium dihydroorotate dehydrogenase ( DHODH ) inhibitor.