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Ephrin Receptor

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Ephrin receptors (Ephs) are a group of receptors that are activated in response to binding ephrin. Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Ephs and their corresponding ephrin ligands are membrane-bound proteins that require direct cell-cell interactions for Eph receptor activation. Eph/ephrin signaling has been implicated in the regulation of a host of processes critical to embryonic development including axon guidance, formation of tissue boundaries, cell migration, and segmentation. Additionally, Eph/epherin signaling has recently been identified to play a critical role in the maintenance of several processes during adulthood including long-term potentiation, angiogenesis, and stem cell differentiation and cancer. The ability of Ephs and ephrins to mediate a variety of cell-cell interactions places the Eph/ephrin system in an ideal position to regulate a variety of different biological processes during embryonic development.

Products Related to Ephrin Receptor(13)

  • GC11134 structure
    GC11134ALW-II-41-27
    CAS: 1186206-79-0
    Purity: >98.00%

    ALW-II-41-27 is an Eph family tyrosine kinase inhibitor with an IC50 of 11 nM to inhibit Eph2.

  • GC14332 structure
    GC14332NVP-BHG712
    CAS: 940310-85-0
    Purity: >99.50%

    EphB4 inhibitor,potent and selective

  • GC18168 structure
    GC18168JI-101
    CAS: 900573-88-8
    Purity: >99.00%

    An orally active inhibitor

  • GC25367 structure
    GC25367Ehp-inhibitor-1
    CAS: 861249-59-4
    Purity: >98%

    Ehp-inhibitor-1 (Ehp inhibitor 2) is an Eph family tyrosine kinase inhibitor that targets Eph receptors.

  • GC31752 structure
    GC31752Tesevatinib (XL-647)
    CAS: 781613-23-8
    Purity: >98.00%

    Tesevatinib (XL-647) (XL-647; EXEL-7647; KD-019) is an orally available, multi-target tyrosine kinase inhibitor; inhibits EGFR, ErbB2, KDR, Flt4 and EphB4 kinase with IC50s of 0.3, 16, 1.5, 8.7, and 1.4 nM.

  • GC35053 structure
    GC35053123C4
    CAS: 2034159-30-1
    Purity: >98%

    123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase EPHA4, with a Ki value of 0.65 μM.

  • GC36782 structure
    GC36782NVP-BHG712 isomer
    CAS: 2245892-85-5
    Purity: >99.00%

    NVP-BHG712 isomer, a regioisomer of NVP-BHG712, shows conserved non-bonded binding to EPHA2 and EPHB4.

  • GC50137 structure
    GC50137KYL
    CAS: 676657-00-4
    Purity: >98%

    KYL, an antagonistic peptide, selectively targets EphA4 receptor.

  • GC64856 structure
    GC64856UniPR129
    CAS: 1639159-47-9
    Purity: >99.00%

    UniPR129 is a potent Eph/ephrin antagonist. UniPR129 has the potential for the research of cancer disease.

  • GC68647 structure
    GC68647ALW-II-49-7
    CAS: 1135219-23-6
    Purity: >98.00%

    ALW-II-49-7 is a selective EphB2 kinase inhibitor with an IC 50 value of 40nM.

  • GC69258 structure
    GC69258Ifabotuzumab
    CAS: 2147698-66-4
    Purity: >95.00%

    Ifabotuzumab (KB004) is an IgG1κ antibody that targets EphA3 (KD=610 pM). Ifabotuzumab can induce apoptosis in tumor cells and activate antibody-dependent cell-mediated cytotoxicity (ADCC), which destroys the tumor vascular system. Ifabotuzumab can reduce CCR10+ cells in idiopathic pulmonary fibrosis (IPF) patients, improving lung fibrosis.

  • GC70097 structure
    GC70097Urolithin D
    CAS: 131086-98-1
    Purity: >98.00%

    Urolithin D is a competitive and reversible antagonist of the EphA receptor. Urolithin D exhibits intra-class selectivity.

  • GC74367 structure
    GC74367Targefrin
    CAS: 3031514-44-7
    Purity: >99.00%

    Targefrin is a potent EphA2-targeting agent, acts as an antagonist.