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FAAH

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Fatty acid amide hydrolase (FAAH), belonging to an amidase-signature (AS) protein family, is a membrane-bound protein predominantly in microsomal and mitochondrial fractions that catalyzes the hydrolysis of several bioactive lipids, including anandamide, 2-arachidonoylglycerol (2-AG) and oleamide. The mammalian FAAHs are 63 kDa (579 amino acids in length) proteins characterized by containing several domains defined by homology and function, including, a highly conserved seine-and-glycine-rich AS domain, a predicted transmembrane domain and a proline rich domain. Results of mutation studies suggest, unlike other members of AS protein family, the catalytic activity of FAAH is not associated with the Ser-His-Asp triad but possibly with Ser217 and Lys142.

Products Related to FAAH(36)

  • GC11290 structure
    GC11290TC-F 2
    CAS: 1304778-15-1
    Purity: >98%

    FAAH inhibitor

  • GC12693 structure
    GC12693JZL 195
    CAS: 1210004-12-8
    Purity: >98.00%

    JZL 195 is a highly selective and irreversible dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), with IC 50 values of 2nM and 4nM, respectively.

  • GC15077 structure
    GC15077SA 47
    CAS: 792236-07-8
    Purity: >99.00%

    FAAH inhibitor

  • GC15358 structure
    GC15358PF 750
    CAS: 959151-50-9
    Purity: >98.00%

    FAAH inhibitor

  • GC17855 structure
    GC17855SA 57
    CAS: 1346169-63-8
    Purity: >98%

    FAAH inhibitor

  • GC10133 structure
    GC10133JNJ-42165279
    CAS: 1346528-50-4
    Purity: >99.50%

    FAAH inhibitor

  • GC12031 structure
    GC12031Monoacylglycerol Lipase Inhibitor 21
    CAS: 1643657-35-5
    Purity: >98%

    inhibitor of monoacylglycerol lipase (MAGL) and FAAH

  • GC12546 structure
    GC12546JP83
    CAS: 887264-44-0
    Purity: >98%

    irreversible fatty acyl amide hydrolase (FAAH) inhibitor

  • GC13063 structure
    GC13063N-Benzylpalmitamide
    CAS: 74058-71-2
    Purity: >98.00%

    inhibitor of fatty acid amide hydrolase (FAAH)

  • GC13953 structure
    GC13953Methyl α-Linolenyl Fluorophosphonate
    Purity: >98%

    inhibitor of phospholipases, FAAH

  • GC13963 structure
    GC13963Oleyl Trifluoromethyl Ketone
    CAS: 177987-23-4
    Purity: >98%

    potent inhibitor of FAAH

  • GC14581 structure
    GC14581JNJ-1661010
    CAS: 681136-29-8
    Purity: >98.50%

    A selective FAAH inhibitor

  • GC15094 structure
    GC15094LY2183240
    CAS: 874902-19-9
    Purity: >99.00%

    A potent, competitive inhibitor of anandamide uptake

  • GC15210 structure
    GC15210PF-622
    CAS: 898235-65-9
    Purity: >98%

    potent, time-dependent, irreversible FAAH inhibitor

  • GC15231 structure
    GC15231Oleoyl Ethyl Amide
    CAS: 85075-82-7
    Purity: >98.00%

    FAAH inhibitor with potential analgesic and anxiolytic activity

  • GC15951 structure
    GC15951URB597
    CAS: 546141-08-6
    Purity: >98.00%

    URB597 is an orally active fatty acid amide hydrolase (FAAH) inhibitor (IC 50 =0.5-5nM).

  • GC16033 structure
    GC16033TAK 21d
    CAS: 1143578-94-2
    Purity: >98%

    TAK 21d (compound 21d) is a potent, orally active and cross the blood-brain barrier fatty acid amide hydrolase (FAAH) inhibitor with IC50s of 0.72, 0.28 nM for hFAAH, rFAAH, respectively.

  • GC16984 structure
    GC16984PF-3845
    CAS: 1196109-52-0
    Purity: >99.50%

    PF-3845 is a dual inhibitor targeting fatty acid amide hydrolase (FAAH) and soluble epoxide hydrolase (sEH), with EC 50 values of 0.65nM and 12000nM, respectively.

  • GC17159 structure
    GC171594-(n-nonyl) Benzeneboronic Acid
    CAS: 256383-45-6
    Purity: >98%

    4-(n-nonyl) Benzeneboronic Acid (compound 13) is a potent FAAH and MAGL dual inhibitor with IC50 values of 9.1 nM and 7.9 μM, respectively.

  • GC17341 structure
    GC17341Carprofen
    CAS: 53716-49-7
    Purity: >99.50%

    COX inhibitor

  • GC18174 structure
    GC18174BIA 10-2474
    CAS: 1233855-46-3
    Purity: >98.00%

    BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme).

  • GC30366 structure
    GC30366FAAH-IN-2
    CAS: 184475-71-6
    Purity: >99.40%

    FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent FAAH(fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2.

  • GC30751 structure
    GC30751FAAH-IN-1
    CAS: 1242441-47-9
    Purity: >98%

    FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.

  • GC31239 structure
    GC31239SA72
    CAS: 934809-60-6
    Purity: >98%

    SA72 is a highly selective fatty acid amide hydrolase (FAAH) inhibitor.