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Methyl α-Linolenyl Fluorophosphonate (Synonyms: MLnFP)

Catalog No.GC13953

inhibitor of phospholipases, FAAH

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Methyl α-Linolenyl Fluorophosphonate Chemical Structure

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1mg
$121.00
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5mg
$535.00
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10mg
$948.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Methyl α-Linolenyl Fluorophosphonate is an inhibitor of phospholipases.

Methyl α-linolenyl fluorophosphonate (MLnFP), an analog of methyl arachidonyl fluorophosphonate (MAFP), has not been completely investigated for its pharmacological activity.

In vitro: Methyl arachidonyl fluorophosphonate (MAFP) was reported to be a selective, active-site directed, irreversible inhibitor of cytosolic phospholipase A2 (cPLA2). MAFP could also potently inhibit the Ca2+-independent cytosolic phospholipase A2 (iPLA2) in a concentration-dependent manner. Such inhibition was not reversed upon extensive dilution of the enzyme into the assay mixture. Preincubation of iPLA2 with MAFP led to a linear and time-dependent inactivation of enzyme activity, and the enzyme was protected from inactivation by the reversible inhibitor. The ability of MAFP to inhibit the iPLA 2 indicated that this enzyme proceeded via an acyl-enzyme intermediate. Further testing showed that MAFP could not inhibit the CoA-dependent acyltransferase, arachidonoyI-CoA synthetase, or CoA-independent transacylase activities. Therefore, MAFP was not a general inhibitor for enzymes acting on arachidonoyi substrates [1].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Lio, Y. C.,Reynolds, L.J.,Balsinde, J., et al. Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochimica et Biophysica Acta 1302, 55-60 (1996).

Chemical Properties

Cas No. SDF
Synonyms MLnFP
Chemical Name 9Z,12Z,15Z-octadecatrienyl-phosphonofluoridic acid, methyl ester
Canonical SMILES CC/C=C\C/C=C\C/C=C\CCCCCCCCP(=O)(F)OC
Formula C19H34FO2P M.Wt 344.4
Solubility ≤5mg/ml in ethanol;5mg/ml in DMSO;5mg/ml in dimethyl formamide Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.9036 mL 14.518 mL 29.036 mL
5 mM 0.5807 mL 2.9036 mL 5.8072 mL
10 mM 0.2904 mL 1.4518 mL 2.9036 mL
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