FFAR1 (GPR40)

GPR40 (Free fatty acid receptor 1, FFA1) is a class A G-protein coupled receptor that in humans is encoded by the FFAR1 gene. It is strongly expressed in the cells of the pancreas and to a lesser extent in the brain. This membrane protein binds free fatty acids, acting as a nutrient sensor for regulating energy homeostasis. GPR40 is activated by medium to long chain fatty acids. GPR40 is most strongly activated by eicosatrienoic acid, but has been found to be activated by fatty acids as small as 10 carbons long. For saturated fatty acids the level of activation is dependent on the length of the carbon chain, which is not true for unsaturated fatty acids. It has been found that three hydrophilic residues (arginine-183, asparagine-244, and arginine-258) anchor the carboxylate group of a fatty acid, which activates GPR40.

Products Related to FFAR1 (GPR40)(20)

GC10922 TUG 424
CAS: 1082058-99-8
Purity: >98.00%
FFA1 (GPR40) agonist
GC12401 GW9508
CAS: 885101-89-3
Purity: >98.00%
FFA1/GPR40 agonist,potent and selective
GC14027 GW-1100
CAS: 306974-70-9
Purity: >98%
A selective GPR40 antagonist
GC16054 TUG-770
CAS: 1402601-82-4
Purity: >99.50%
An agonist of FFA1/GPR40
GC16555 TAK-875
CAS: 1000413-72-8
Purity: >98.50%
TAK-875 is a potent, selective and orally bioavailable GPR40 (G protein-coupled receptor 40) agonist with an EC 50 value of 0.014μM for human GPR40.
GC18125 DC260126
CAS: 346692-04-4
Purity: >98.00%
free fatty acid receptor 1 (FFAR1/GPR40) antagonist
GC19030 AMG 837
CAS: 865231-46-5
Purity: >98%
AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents
GC31389 GPR40 Activator 2
CAS: 1312787-30-6
Purity: >99.50%
GPR40 Activator 2 is a potent GPR40 activator from patents WO 2012147516 A1, WO 2012046869A1 and WO 2011078371 A1.
GC31410 FAA1 agonist-1
CAS: 2102196-57-4
Purity: >98.50%
FAA1 agonist-1 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.
GC31607 AM-1638
CAS: 1142214-62-7
Purity: >99.50%
AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC50 of 0.16 μM.
GC31634 GPR40 Agonist 2
CAS: 1147729-48-3
Purity: >98%
GPR40 Agonist 2 is a GPR40 agonist that can be used in the research of diabetes, extracted from patent WO2009054479A1.
GC31698 PBI-4050 sodium salt (Setogepram (sodium salt))
CAS: 1254472-97-3
Purity: >99.50%
Fezagepras (Setogepram) sodium acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84.
GC32481 Vincamine
CAS: 1617-90-9
Purity: >99.50%
A plant alkaloid with vasodilator effects
GC34464 AM-4668
CAS: 1011531-27-3
Purity: >99.00%
AM-4668 is a GPR40 agonist for type 2 diabetes.
GC35313 AMG 837 calcium hydrate
CAS: 1259389-38-2
Purity: >98%
AMG 837 calcium hydrate is a potent, orally bioavailable and partial agonist of GPR40/FFA1.
GC35314 AMG 837 sodium salt
CAS: 865231-45-4
Purity: >98%
AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
GC35364 AP5
CAS: 1623194-37-5
Purity: >98%
AP5 is a potent, orlly active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM).
GC36185 GPR40 Activator 1
CAS: 1309435-60-6
Purity: >98.50%
GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes.
GC36507 LY2922470
CAS: 1423018-12-5
Purity: >99.50%
LY2922470 is a potent, selective and orally available agonist of the G protein-coupled receptor 40 (GPR40), with EC50s of 7 nM, 1 nM and 3 nM for human GPR40, mouse GPR40 and rat GPR40, respectively.
GC63010 HWL-088
CAS: 2378617-96-8
Purity: >98.50%
HWL-088 is a highly potent and orally active free fatty acid receptor 1 (FFA1/GPR40) agonist (EC50 of 18.9 nM) with moderate PPARδ activity (EC50 of 570.9 nM) .

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC10922	TUG 424	1082058-99-8	>98.00%
GC10922	FFA1 (GPR40) agonist
GC12401	GW9508	885101-89-3	>98.00%
GC12401	FFA1/GPR40 agonist,potent and selective
GC14027	GW-1100	306974-70-9	>98%
GC14027	A selective GPR40 antagonist
GC16054	TUG-770	1402601-82-4	>99.50%
GC16054	An agonist of FFA1/GPR40
GC16555	TAK-875	1000413-72-8	>98.50%
GC16555	TAK-875 is a potent, selective and orally bioavailable GPR40 (G protein-coupled receptor 40) agonist with an EC 50 value of 0.014μM for human GPR40.
GC18125	DC260126	346692-04-4	>98.00%
GC18125	free fatty acid receptor 1 (FFAR1/GPR40) antagonist
GC19030	AMG 837	865231-46-5	>98%
GC19030	AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents
GC31389	GPR40 Activator 2	1312787-30-6	>99.50%
GC31389	GPR40 Activator 2 is a potent GPR40 activator from patents WO 2012147516 A1, WO 2012046869A1 and WO 2011078371 A1.
GC31410	FAA1 agonist-1	2102196-57-4	>98.50%
GC31410	FAA1 agonist-1 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.
GC31607	AM-1638	1142214-62-7	>99.50%
GC31607	AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC50 of 0.16 μM.
GC31634	GPR40 Agonist 2	1147729-48-3	>98%
GC31634	GPR40 Agonist 2 is a GPR40 agonist that can be used in the research of diabetes, extracted from patent WO2009054479A1.
GC31698	PBI-4050 sodium salt (Setogepram (sodium salt))	1254472-97-3	>99.50%
GC31698	Fezagepras (Setogepram) sodium acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84.
GC32481	Vincamine	1617-90-9	>99.50%
GC32481	A plant alkaloid with vasodilator effects
GC34464	AM-4668	1011531-27-3	>99.00%
GC34464	AM-4668 is a GPR40 agonist for type 2 diabetes.
GC35313	AMG 837 calcium hydrate	1259389-38-2	>98%
GC35313	AMG 837 calcium hydrate is a potent, orally bioavailable and partial agonist of GPR40/FFA1.
GC35314	AMG 837 sodium salt	865231-45-4	>98%
GC35314	AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
GC35364	AP5	1623194-37-5	>98%
GC35364	AP5 is a potent, orlly active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM).
GC36185	GPR40 Activator 1	1309435-60-6	>98.50%
GC36185	GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes.
GC36507	LY2922470	1423018-12-5	>99.50%
GC36507	LY2922470 is a potent, selective and orally available agonist of the G protein-coupled receptor 40 (GPR40), with EC50s of 7 nM, 1 nM and 3 nM for human GPR40, mouse GPR40 and rat GPR40, respectively.
GC63010	HWL-088	2378617-96-8	>98.50%
GC63010	HWL-088 is a highly potent and orally active free fatty acid receptor 1 (FFA1/GPR40) agonist (EC50 of 18.9 nM) with moderate PPARδ activity (EC50 of 570.9 nM) .