GLPBio

FLT3

FLT3 (FMS-like tyrosine kinase 3) is a cytokine receptor which belongs to the receptor tyrosine kinase class III and plays a role in cell survival, proliferation, and differentiation.

Products Related to FLT3(95)

  • GC12058 structure
    GC12058TCS 359
    CAS: 301305-73-7
    Purity: >99.50%

    Potent FLT3 inhibitor

  • GC14396 structure
    GC14396Ponatinib (AP24534)
    CAS: 943319-70-8
    Purity: >99.00%

    Ponatinib (AP24534) (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

  • GC15779 structure
    GC15779Cabozantinib (XL184, BMS-907351)
    CAS: 849217-68-1
    Purity: >99.50%

    Cabozantinib (XL184, BMS-907351) is an orally bioavailable and potent inhibitor of MET and VEGFR2 with IC 50 values of 1.3nM and 0.035nM, respectively.

  • GC17958 structure
    GC17958Linifanib (ABT-869)
    CAS: 796967-16-3
    Purity: >98.00%

    Linifanib (ABT-869) (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (ABT-869) shows prominent antitumor activity. Linifanib (ABT-869) has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib (ABT-869) is a specific miR-10b inhibitor that blocks miR-10b biogenesis.

  • GC10035 structure
    GC10035TG101209
    CAS: 936091-14-4
    Purity: >99.50%

    An inhibitor of JAK2, FLT3, RET, and JAK3

  • GC10638 structure
    GC10638AT9283
    CAS: 896466-04-9
    Purity: >99.50%

    A broad spectrum kinase inhibitor

  • GC10914 structure
    GC10914AST 487
    CAS: 630124-46-8
    Purity: >99.00%

    A multi-kinase inhibitor

  • GC11057 structure
    GC11057LY2801653 (Merestinib)
    CAS: 1206799-15-6
    Purity: >98.00%

    LY2801653 (Merestinib) is a potent, orally bioavailable c-Met inhibitor (IC 50 =4.7nM; K i value=2nM), with K D values of 20nM, 92nM, and 54nM for NTRK1, NTRK2, and NTRK3, respectively.

  • GC11205 structure
    GC112055'-Fluoroindirubinoxime
    CAS: 861214-33-7
    Purity: >98.00%

    FMS-like receptor tyrosine kinase-3 (FLT3) inhibitor

  • GC11455 structure
    GC11455Silvestrol
    CAS: 697235-38-4
    Purity: >98.00%
  • GC12064 structure
    GC12064SB1317
    CAS: 937270-47-8
    Purity: >99.50%

    A multi-kinase inhibitor

  • GC12145 structure
    GC12145ENMD-2076 L-(+)-Tartaric acid
    CAS: 1291074-87-7
    Purity: >98.50%
  • GC12178 structure
    GC12178G-749
    CAS: 1457983-28-6
    Purity: >98.00%

    FLT3 inhibitor

  • GC12251 structure
    GC12251Tandutinib (MLN518) HCl
    Purity: >98%

    FLT3 inhibitor,potent and selective

  • GC13547 structure
    GC13547Dovitinib (TKI-258, CHIR-258)
    CAS: 405169-16-6
    Purity: >98.00%

    Dovitinib (TKI-258, CHIR-258) (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC50s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, CSF-1R, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively. Dovitinib (TKI-258, CHIR-258) has potent antitumor activity.

  • GC13848 structure
    GC13848LY2784544
    CAS: 1229236-86-5
    Purity: >99.50%

    Potent inhibitor of JAK2

  • GC14007 structure
    GC14007DCC-2036 (Rebastinib)
    CAS: 1020172-07-9
    Purity: >98.00%

    DCC-2036 (Rebastinib) (DCC-2036) is an orally active, non-ATP-competitiveBcr-Abl inhibitor for Abl1WT and Abl1T315I with IC50s of 0.8 nM and 4 nM, respectively. DCC-2036 (Rebastinib) also inhibits SRC, KDR, FLT3, and Tie-2, and has low activity to seen towards c-Kit.

  • GC14582 structure
    GC14582SU5614
    CAS: 1055412-47-9
    Purity: >98%

    SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3.

  • GC14592 structure
    GC14592KW 2449
    CAS: 1000669-72-6
    Purity: >99.50%

    A multi-kinase inhibitor

  • GC14906 structure
    GC14906Crenolanib (CP-868596)
    CAS: 670220-88-9
    Purity: >99.50%

    Crenolanib (CP-868596) is a potent and selective inhibitor of wild-type and mutant isoforms of the class III receptor tyrosine kinases FLT3 and PDGFRα/β with Kds of 0.74 nM and 2.1 nM/3.2 nM, respectively.

  • GC14974 structure
    GC14974AMG 925
    CAS: 1401033-86-0
    Purity: >98.00%

    AMG 925 is an orally active dual FLT3 and CDK4 kinase inhibitor (IC 50 =1nM and 3nM).

  • GC15307 structure
    GC15307SU5416
    CAS: 204005-46-9
    Purity: >98.00%

    SU5416 is a small-molecule Flk-1/KDR inhibitor that inhibits autophosphorylation of the Flk-1 receptor, with an IC 50 value of 1.23μM.

  • GC15556 structure
    GC15556UNC2025
    CAS: 1429881-91-3
    Purity: >99.50%

    orally bioavailable dual MER/FLT3 inhibitor

  • GC15739 structure
    GC15739CHIR-124
    CAS: 405168-58-3
    Purity: >98.00%

    Chk1 inhibitor,novel and potent