Fludioxonil (Synonyms: CGA 173506)

Fludioxonil is a phenylpyrrole fungicide.¹ It inhibits the growth of B. cinerea isolates from strawberry and blackberry crops (EC₅₀s = 0.06-0.38 mg/L).² Fludioxonil also inhibits the growth of S. cerevisiae AF293 and C. albicans IFO1385 in a concentration-dependent manner.^1,3 It is an estrogen receptor α (ERα) agonist (EC₅₀ = 3.7 μM in a yeast reporter assay) that induces expression of the oncogenic microRNA miR-21, inhibits estradiol-induced proliferation, and reduces cell motility of MCF-7 breast cancer cells in vitro.⁴

1.Kim, J.H., Campbell, B.C., Mahoney, N., et al.Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress responseLett. Appl. Microbiol.45(2)134-141(2007) 2.Li, X., FernÁndez-OrtuÑo, D., Grabke, A., et al.Resistance to fludioxonil in Botrytis cinerea isolates from blackberry and strawberryPhytopathology104(7)724-732(2014) 3.Ochiai, N., Fujimura, M., Oshima, M., et al.Effects of iprodione and fludioxonil on glycerol synthesis and hyphal development in Candida albicansBiosci. Biotechnol. Biochem.66(10)2209-2215(2002) 4.Teng, Y., Manavalan, T.T., Hu, C., et al.Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cellsToxicol. Sci.131(1)71-83(2013)