Fludioxonil is a phenylpyrrole fungicide.1 It inhibits the growth of B. cinerea isolates from strawberry and blackberry crops (EC50s = 0.06-0.38 mg/L).2 Fludioxonil also inhibits the growth of S. cerevisiae AF293 and C. albicans IFO1385 in a concentration-dependent manner.1,3 It is an estrogen receptor α (ERα) agonist (EC50 = 3.7 μM in a yeast reporter assay) that induces expression of the oncogenic microRNA miR-21, inhibits estradiol-induced proliferation, and reduces cell motility of MCF-7 breast cancer cells in vitro.4
1.Kim, J.H., Campbell, B.C., Mahoney, N., et al.Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress responseLett. Appl. Microbiol.45(2)134-141(2007) 2.Li, X., FernÁndez-OrtuÑo, D., Grabke, A., et al.Resistance to fludioxonil in Botrytis cinerea isolates from blackberry and strawberryPhytopathology104(7)724-732(2014) 3.Ochiai, N., Fujimura, M., Oshima, M., et al.Effects of iprodione and fludioxonil on glycerol synthesis and hyphal development in Candida albicansBiosci. Biotechnol. Biochem.66(10)2209-2215(2002) 4.Teng, Y., Manavalan, T.T., Hu, C., et al.Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cellsToxicol. Sci.131(1)71-83(2013)