Anti-Mouse TREM2 Antibody (178) is an antibody targeting mouse TREM2, which blocks the binding of ligands to TREM2 and inhibits TREM2 -mediated signaling pathways. Anti-Mouse TREM2 Antibody (178) inhibits the tumor growth of MCA/1956 sarcoma in mice. Anti-Mouse TREM2 Antibody (178) enhances IFNγ production by intratumoral CD8 + T cells and TNFα production by intratumoral CD4 + T cells. Anti-Mouse TREM2 Antibody (178) can be used in the research of sarcoma, colorectal cancer and breast tumors. The recommended isotype control is Rat IgG2a kappa, Isotype Control [1].
In Vivo, Anti-Mouse TREM2 Antibody (178) (200 μg per mouse; i.p.; once every 5 days; initiated on day 2 after tumor inoculation) significantly inhibits the growth of MCA/1956 sarcomas in mice. When combined with a suboptimal dose of anti-PD-1, it achieves complete tumor regression, while also reshaping the intratumoral myeloid cell population and enhancing T cell effector functions[1].
In Vitro, The Anti-Mouse TREM2 Antibody (178) (20 μg/mL; overnight) blocks ligand-induced activation of mouse TREM2 in stably transfected 2B4 reporter cells at a concentration of 20 μg/mL[1].
References:
[1]. Molgora M, et al. TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy. Cell. 2020 Aug 20;182(4):886-900.e17.
In Vivo, Anti-Mouse TREM2 Antibody (178) (200 μg per mouse; i.p.; once every 5 days; initiated on day 2 after tumor inoculation) significantly inhibits the growth of MCA/1956 sarcomas in mice. When combined with a suboptimal dose of anti-PD-1, it achieves complete tumor regression, while also reshaping the intratumoral myeloid cell population and enhancing T cell effector functions[1].
In Vitro, The Anti-Mouse TREM2 Antibody (178) (20 μg/mL; overnight) blocks ligand-induced activation of mouse TREM2 in stably transfected 2B4 reporter cells at a concentration of 20 μg/mL[1].
References:
[1]. Molgora M, et al. TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy. Cell. 2020 Aug 20;182(4):886-900.e17.