FzM1 (Synonyms: Frizzled M1) |
Catalog No.GC41534 |
FzM1 est un modulateur allostérique négatif (NAM) du récepteur Frizzled FZD4. FzM1 réduit l'activité de l'élément réactif WNT (WRE) dépendant de WNT5A (log EC50inh = -6,2). FzM1 se lie À un site de liaison allostérique situé dans la boucle intracellulaire 3 (ICL3) de FZD4 et modifie la conformation du récepteur, inhibant finalement la cascade WNT/β-caténine.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1680196-54-6
Sample solution is provided at 25 µL, 10mM.
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4. At 10 µM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway. FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.
Average Rating: 5
(Based on Reviews and 12 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *