dBET57 |
| Catalog No.GC35815 |
dBET57 est un dégradeur puissant et sélectif de BRD4BD1 basé sur la technologie PROTAC. dBET57 intervient dans le recrutement de l'ubiquitine ligase CRL4Cereblon E3, avec un DC50/5h de 500 nM pour BRD4BD1, et est inactif sur BRD4BD2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1883863-52-2
Sample solution is provided at 25 µL, 10mM.
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dBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology. dBET57 mediates recruitment to the CRL4CRBN E3 ubiquitin ligase, with a DC50/5h of 500 nM for BRD4BD1, and is inactive on BRD4BD2[1]. BRD4 (BD1)|500 nM (DC50)
[1]. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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