EN6 |
| Catalog No.GC35982 |
EN6 est une petite molécule in vivo activateur de l'autophagie qui cible de manière covalente la cystéine 277 dans la sous-unité ATP6V1A de l'ATPase lysosomale vacuolaire H+ (v-ATPase).
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Cas No.: 1808714-73-9
Sample solution is provided at 25 µL, 10mM.
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EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner[1].
[1]. Chung CY, et al. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol. 2019 Aug;15(8):776-785.
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