10β,17β-dihydroxyestra-1,4-dien-3-one (Synonyms: DHED) |
| Catalog No.GC38542 |
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) est un promédicament bioprécurseur ciblant le cerveau du principal œstrogène humain, le 17β-estradiol, atténuant les bouffées de chaleur chez les rats modèles de dysfonctionnement thermorégulateur du cerveau.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 549-02-0
Sample solution is provided at 25 µL, 10mM.
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10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1].
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is an inactive bioprecursor prodrug of 17β-estradiol converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes[1].
[1]. Merchenthaler I, et al. Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery. Sci Rep. 2016 Aug 1;6:30721.
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