HDAC11-IN-4 is a potent and selective HDAC11 inhibitor with an IC50 of 13.49 nM and a K i of 2.2 nM. HDAC11-IN-4 exhibits extremely high selectivity for HDAC11 over other defatty-acylases such as SIRT2, SIRT3, SIRT6, and HDAC8 ( SI >10,000). HDAC11-IN-4 can be used for the research of cancer [1].
References:
[1]. Sebastian Hilscher, et al. Substrate-Guided Development of HDAC11-Selective Inhibitors Featuring α-Amino Amide Zinc-Binding Groups. ACS Omega 2025, 10, 42, 50577–50587
References:
[1]. Sebastian Hilscher, et al. Substrate-Guided Development of HDAC11-Selective Inhibitors Featuring α-Amino Amide Zinc-Binding Groups. ACS Omega 2025, 10, 42, 50577–50587