Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].
Melengestrol acetate (s.c.; 10 mg/kg; 9 days) inhibits the growth of AT3 tumors by approximately 53%. And it also causes a 54% weight reduction of the ventral prostate and a reduction of the seminal vesicles in adult male CCFl rats[1].Melengestrol acetate (oral administration; 10 mg/kg; 24 days) causes a 58.8% Dunning R3327-AT3 tumors growth and reduces the adrenal weight by 51.6% in rat[1].
[1]. G M Padilla, et al. Melengestrol acetate and megestrol acetate are prostatic tumor inhibiting agents. Biochem Cell Biol. 1990 Oct;68(10):1181-8.
[2]. G W DUNCAN, et al. BIOLOGIC EFFECTS OF MELENGESTROL ACETATE. Fertil Steril. Jul-Aug 1964;15:416-32.
[3]. https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/melengestrol-acetate