Nimbin is a limonoid that has been found in neem seeds and has diverse biological activities.1,2,3 It inhibits the growth of the plant pathogenic fungus D. oryzae by 64.8% when used at a concentration of 1,000 ppm.1 Nimbin (0.02-2,000 μM) has antifeedant activity against S. littoralis in a choice test.2 It decreases melanin content to 20.9% of control, without affecting viability, in B16 murine melanoma cells when used at a concentration of 25 μg/ml.3 Nimbin inhibits activation of Epstein-Barr virus early antigen (EBV-EA) induced by phorbol 12-myristate 13-acetate in Raji cells (IC50 = 499 mol ratio/32 pmol TPA).
|3. Akihisa, T., Noto, T., Takahashi, A., et al. Melanogenesis inhibitory, anti-inflammatory, and chemopreventive effects of limonoids from the seeds of Azadirachta indicia A. juss. (neem). J. Oleo. Sci. 58(11), 581-594 (2009).