Bruceine D |
| Catalog No.GC35559 |
Bruceine D est un inhibiteur de Notch avec une activité anticancéreuse et induit l'apoptose dans plusieurs cellules cancéreuses humaines.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 21499-66-1
Sample solution is provided at 25 µL, 10mM.
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Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2]. Notch[1]
Bruceine D inhibits the cell viability of H460 and A549 cells in a dose-dependent manner with IC50 values of 0.5 and 0.6?μM, respectively, at 48?h of treatment[1]. Bruceine D (0.125-1.0?μM) dose-dependently promotes chromatin condensation, Annexin V-positive cell population and caspase-dependent apoptosis in H460 and A549 cells[1].
[1]. Mao G,et al. Bruceine D Isolated from Brucea Javanica (L.) Merr. as a Systemic Feeding Deterrent for Three Major Lepidopteran Pests. J Agric Food Chem. 2019 Apr 17;67(15):4232-4239. [2]. Cheng Z, et al. Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways. Cancer Lett. 2017 Sep 10;403:195-205.
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