PAO-Nap |
| Catalog No.GC61552 |
PAO-Nap est le PAO modifié attaché À un fluorophore de naphtalimide utilisant l'acide aminocaproÏque comme lieur. La PAO induit l'apoptose médiée par le stress oxydatif dans les cellules HL-60 en ciblant sélectivement la thiorédoxine réductase.
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Cas No.: 1613402-20-2
Sample solution is provided at 25 µL, 10mM.
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PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[1].
PAO exhibits IC50 values of 6.2 μM, 9.4 μM, 7.7 μM in HL-60, 7721 and Hela cells (48 h)[1].
[1]. Yaping Liu, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11.
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