(-)-Chaetominine (Synonyms: (-)-Chaetominine) |
Catalog No.GC45246 |
La (-)-chétominine est un métabolite alcaloïde. La (-)-chaetomine a une cytotoxicité contre la leucémie humaine K562 et les lignées cellulaires SW1116 du cancer du côlon. La (-)-chaetomine réduit la résistance aux médicaments médiée par MRP1 en inhibant la voie de signalisation PI3K/Akt/Nrf2 dans les cellules leucémiques humaines K562/Adr.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 918659-56-0
Sample solution is provided at 25 µL, 10mM.
(-)-Chaetominine is a cytotoxic alkaloid originally isolated from Chaetomium sp. IFB-E015. It inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM, respectively). (-)-Chaetominine induces apoptosis of K562 cells via upregulation of the Bax/Bcl-2 ratio, decreasing mitochondrial membrane potential, inducing mitochondrial cytochrome C release, and activation of caspase-3 and caspase-9. It also decreases doxorubicin efflux mediated by multidrug resistance-associated protein 1 (MRP1) and restores sensitivity to doxorubicin in resistant K562 cells.
Average Rating: 5
(Based on Reviews and 17 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *