RPH-2823 |
| Catalog No.GC30414 |
Le RPH-2823, un dérivé basique du triamtérène, induit une diminution dose-dépendante du courant de court-circuit (SCC) et une augmentation de la résistance électrique transépithéliale.
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Cas No.: 96558-24-6
Sample solution is provided at 25 µL, 10mM.
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RPH-2823 is a basic triamterene derivative, with diuretic activity.
RPH 2823 induces a dose-dependent decrease in SCC and increase in transepithelial electrical resistance. RPH 2823 influences transepithelial Na+ transport by interacting with the Na+ channel or a regulator site of it within the apical membrane[1].
RPH 2823 (2.5 mumol/kg) can avoid the kaliuresis of 25 mumol/kg furosemide in male Wistar rats. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) has a terminal elimination half-life of 3 h. About 47% of the given dose are excreted unchanged with urine[2].
[1]. Kipnowski J, et al. Effects of standard diuretics and RPH 2823 on transepithelial Na+ transport in isolated frog skin. Klin Wochenschr. 1986 Aug 15;64(16):750-9. [2]. Priewer H, et al. Pharmacodynamics and pharmacokinetics of the basic triamterene analogue dimethylaminohydroxypropoxytriamterene. Arzneimittelforschung. 1985;35(11):1688-91.
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