R-8507 |
Catalog No.GC44802 |
R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 338773-13-0
Sample solution is provided at 25 µL, 10mM.
R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 µM, respectively, in an ELISA using A549 lung epithelial cells.{|Gururaja2007|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.
Average Rating: 5
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