Hck-IN-1 |
| Catalog No.GC39570 |
Hck-IN-1 (composé B9), un composé diphénylpyrazolo, est un inhibiteur sélectif de Hck dépendant de Nef avec des IC50 de 2,8 μM,> 20 μM pour le complexe Nef: Hck et Hck, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1473404-51-1
Sample solution is provided at 25 µL, 10mM.
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Hck-IN-1 (compound B9), a diphenylpyrazolo compound, is a selective Nef-dependent Hck inhibitor with IC50s of 2.8 μM, >20 μM for Nef:Hck complex and Hck, respectively. Hck-IN-1 is a direct and wide HIV-1 Nef antagonists with an IC50 of 100-300 nM for wild-type HIV-1 replication. Hck-IN-1 binds pocket residue Asn126 and has anti-retroviral activity[1].
[1]. Emert-Sedlak LA, et al. Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity. Chem Biol. 2013 Jan 24;20(1):82-91.
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