Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
Products Related to Drug Metabolite(546)
- GC422753-hydroxy DesloratidineCAS: 119410-08-1Purity: >98.00%
3-hydroxy Desloratidine is a major metabolite of desloratadine , a tricyclic antagonist of the histamine H1 receptor.
- GC423073-O-methyl-L-DOPA (hydrate)CAS: 200630-46-2Purity: >98.00%
3-O-methyl-L-DOPA is a metabolite of L-DOPA, produced by the activity of catechol O-methyltransferase.
- GC423704-desmethoxy OmeprazoleCAS: 110374-16-8Purity: >98.00%
Le 4-desméthoxy oméprazole est le métabolite actif de l'oméprazole.
- GC424014-hydroperoxy CyclophosphamideCAS: 39800-16-3Purity: >95.00%
4-hydroperoxy Cyclophosphamide, métabolite actif du cyclophosphamide, peut réticuler l'ADN et induire l'apoptose des cellules T indépendamment de l'activation du récepteur de la caspase. Il active également la voie de la mort mitochondriale par la production d'espèces réactives de l'oxygène (ROS).
- GC424024-hydroxy (S)-Duloxetine β-D-Glucuronide (sodium salt)Purity: >95.00%
4-hydroxy (S)-Duloxetine β-D-glucuronide is an inactive metabolite of the serotonin and norepinephrine reuptake inhibitor (S)-duloxetine.
- GC424054-hydroxy Atorvastatin (calcium salt)CAS: 265989-44-4Purity: >90.00%
4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.
- GC424074-hydroxy DiclofenacCAS: 64118-84-9Purity: >97.00%
Le 4-hydroxy diclofénac est un métabolite actif du diclofénac par voie orale par le cytochrome P450 2C9 (CYP2C9).
- GC424094-hydroxy Nebivolol (hydrochloride)CAS: 2717115-85-8Purity: >98.00%
4-hydroxy Nebivolol is a major metabolite of nebivolol.
- GC424154-hydroxy ValsartanCAS: 188259-69-0Purity: >98.00%
4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan.
- GC425465-hydroxy DiclofenacCAS: 69002-84-2Purity: >98.00%
5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4.
- GC425485-hydroxy Saxagliptin (hydrochloride)Purity: >95.00%
5-hydroxy Saxagliptin is a major active metabolite of saxagliptin.
- GC425495-hydroxy ThiabendazoleCAS: 948-71-0Purity: >98%
5-hydroxy Thiabendazole (5-OH TBZ) is a major metabolite of the anthelmintic thiabendazole.
- GC425505-hydroxy-6-methoxy (S)-DuloxetineCAS: 741693-79-8Purity: >95.00%
5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine.
- GC425515-hydroxymethyl Tolterodine (formate)CAS: 380636-49-7Purity: >98.00%
5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine and fesoterodine.
- GC425806-hydroxy ChlorzoxazoneCAS: 1750-45-4Purity: >97.00%
6-hydroxy Chlorzoxazone est le métabolite principal du chlorzoxazone in vivo. 6-hydroxy Chlorzoxazone est principalement formé via le système enzymatique cytochrome P450 hépatique, est couramment utilisé comme sonde en recherche biochimique pour évaluer quantitativement l'activité CYP2E1.
- GC425846-O-desmethyl DonepezilCAS: 120013-56-1Purity: >98.00%
6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil.
- GC425866α-hydroxy PaclitaxelCAS: 153212-75-0Purity: >95.00%
6α-hydroxy Paclitaxel est un métabolite primaire du Paclitaxel. 6α-hydroxy Le paclitaxel conserve un effet dépendant du temps sur les polypeptides transporteurs d'anions organiques 1B1/SLCO1B1 (OATP1B1) avec une puissance d'inhibition similaire À celle du paclitaxel, alors qu'il n'a plus montré d'inhibition dépendante du temps de l'OATP1B3. 6α-hydroxy Paclitaxel peut être utilisé pour la recherche sur le cancer.
- GC426067-hydroxy Coumarin Glucuronide (sodium salt)CAS: 168286-98-4Purity: >95.00%
7-hydroxy Coumarin Glucuronide (sodium salt) is a phase II metabolite of 7-hydroxycoumarin formed by glucuronidation.
- GC426077-hydroxy Coumarin sulfate (potassium salt)CAS: 1135316-80-1Purity: >98.00%
7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS.
- GC426087-hydroxy Methotrexate (sodium salt)Purity: >96.00%
7-hydroxy Methotrexate (7-hydroxy MTX) is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases.
- GC426268-hydroxy EfavirenzCAS: 205754-33-2Purity: >98.00%
8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz.
- GC426339(E)-Erythromycin A oximeCAS: 111321-02-9Purity: >95.00%
(9E)-Erythromycin A oxime is a metabolite of the semisynthetic antibiotic roxithromycin .
- GC42667Abacavir CarboxylateCAS: 384380-52-3Purity: >95.00%
Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir.
- GC42690Acecainide (hydrochloride)CAS: 34118-92-8Purity: >98.00%
Acecainide is an active metabolite of the class III antiarrhythmic procainamide.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC42275 | 3-hydroxy Desloratidine | 119410-08-1 | >98.00% | |
3-hydroxy Desloratidine is a major metabolite of desloratadine , a tricyclic antagonist of the histamine H1 receptor. | ||||
| GC42307 | 3-O-methyl-L-DOPA (hydrate) | 200630-46-2 | >98.00% | |
3-O-methyl-L-DOPA is a metabolite of L-DOPA, produced by the activity of catechol O-methyltransferase. | ||||
| GC42370 | 4-desmethoxy Omeprazole | 110374-16-8 | >98.00% | |
Le 4-desméthoxy oméprazole est le métabolite actif de l'oméprazole. | ||||
| GC42401 | 4-hydroperoxy Cyclophosphamide | 39800-16-3 | >95.00% | |
4-hydroperoxy Cyclophosphamide, métabolite actif du cyclophosphamide, peut réticuler l'ADN et induire l'apoptose des cellules T indépendamment de l'activation du récepteur de la caspase. Il active également la voie de la mort mitochondriale par la production d'espèces réactives de l'oxygène (ROS). | ||||
| GC42402 | 4-hydroxy (S)-Duloxetine β-D-Glucuronide (sodium salt) | - | >95.00% | |
4-hydroxy (S)-Duloxetine β-D-glucuronide is an inactive metabolite of the serotonin and norepinephrine reuptake inhibitor (S)-duloxetine. | ||||
| GC42405 | 4-hydroxy Atorvastatin (calcium salt) | 265989-44-4 | >90.00% | |
4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. | ||||
| GC42407 | 4-hydroxy Diclofenac | 64118-84-9 | >97.00% | |
Le 4-hydroxy diclofénac est un métabolite actif du diclofénac par voie orale par le cytochrome P450 2C9 (CYP2C9). | ||||
| GC42409 | 4-hydroxy Nebivolol (hydrochloride) | 2717115-85-8 | >98.00% | |
4-hydroxy Nebivolol is a major metabolite of nebivolol. | ||||
| GC42415 | 4-hydroxy Valsartan | 188259-69-0 | >98.00% | |
4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan. | ||||
| GC42546 | 5-hydroxy Diclofenac | 69002-84-2 | >98.00% | |
5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4. | ||||
| GC42548 | 5-hydroxy Saxagliptin (hydrochloride) | - | >95.00% | |
5-hydroxy Saxagliptin is a major active metabolite of saxagliptin. | ||||
| GC42549 | 5-hydroxy Thiabendazole | 948-71-0 | >98% | |
5-hydroxy Thiabendazole (5-OH TBZ) is a major metabolite of the anthelmintic thiabendazole. | ||||
| GC42550 | 5-hydroxy-6-methoxy (S)-Duloxetine | 741693-79-8 | >95.00% | |
5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine. | ||||
| GC42551 | 5-hydroxymethyl Tolterodine (formate) | 380636-49-7 | >98.00% | |
5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine and fesoterodine. | ||||
| GC42580 | 6-hydroxy Chlorzoxazone | 1750-45-4 | >97.00% | |
6-hydroxy Chlorzoxazone est le métabolite principal du chlorzoxazone in vivo. 6-hydroxy Chlorzoxazone est principalement formé via le système enzymatique cytochrome P450 hépatique, est couramment utilisé comme sonde en recherche biochimique pour évaluer quantitativement l'activité CYP2E1. | ||||
| GC42584 | 6-O-desmethyl Donepezil | 120013-56-1 | >98.00% | |
6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil. | ||||
| GC42586 | 6α-hydroxy Paclitaxel | 153212-75-0 | >95.00% | |
6α-hydroxy Paclitaxel est un métabolite primaire du Paclitaxel. 6α-hydroxy Le paclitaxel conserve un effet dépendant du temps sur les polypeptides transporteurs d'anions organiques 1B1/SLCO1B1 (OATP1B1) avec une puissance d'inhibition similaire À celle du paclitaxel, alors qu'il n'a plus montré d'inhibition dépendante du temps de l'OATP1B3. 6α-hydroxy Paclitaxel peut être utilisé pour la recherche sur le cancer. | ||||
| GC42606 | 7-hydroxy Coumarin Glucuronide (sodium salt) | 168286-98-4 | >95.00% | |
7-hydroxy Coumarin Glucuronide (sodium salt) is a phase II metabolite of 7-hydroxycoumarin formed by glucuronidation. | ||||
| GC42607 | 7-hydroxy Coumarin sulfate (potassium salt) | 1135316-80-1 | >98.00% | |
7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS. | ||||
| GC42608 | 7-hydroxy Methotrexate (sodium salt) | - | >96.00% | |
7-hydroxy Methotrexate (7-hydroxy MTX) is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases. | ||||
| GC42626 | 8-hydroxy Efavirenz | 205754-33-2 | >98.00% | |
8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz. | ||||
| GC42633 | 9(E)-Erythromycin A oxime | 111321-02-9 | >95.00% | |
(9E)-Erythromycin A oxime is a metabolite of the semisynthetic antibiotic roxithromycin . | ||||
| GC42667 | Abacavir Carboxylate | 384380-52-3 | >95.00% | |
Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir. | ||||
| GC42690 | Acecainide (hydrochloride) | 34118-92-8 | >98.00% | |
Acecainide is an active metabolite of the class III antiarrhythmic procainamide. | ||||