4-hydroxy Diclofenac |
| Catalog No.GC42407 |
Le 4-hydroxy diclofénac est un métabolite actif du diclofénac par voie orale par le cytochrome P450 2C9 (CYP2C9).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 64118-84-9
Sample solution is provided at 25 µL, 10mM.
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4-hydroxy Diclofenac is a CYP2C9 metabolite of the NSAID diclofenac.[1] [2] [3] By inhibiting COX and subsequently suppressing PGE2 synthesis, it demonstrates anti-inflammatory and analgesic properties.[4]
Reference:
[1]. Shimamoto, J., Ieiri, I., Urae, A., et al. Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9*3 allele. European Journal of Clinical Pharmacology 56, 65-68 (2000).
[2]. Sawchuk, R.J., Maloney, J.A., Cartier, L.L., et al. Analysis of diclofenac and four of its metabolites in human urine by HPLC. Pharm. Res. 12(5), 756-762 (1995).
[3]. Godbillon, J., Gauron, S., and Metayer, J.P. High-performance liquid chromatographic determination of diclofenac and its monohydroxylated metabolities in biological fluids. Journal of Chromatography 27, 151-159 (1985).
[4]. Yamakazi, R., Kawai, S., Matsumoto, T., et al. Hydrolytic activity is essential for aceclofenac to inhibit cyclooxygenase in rheumatoid synovial cells. Journal of Pharmacology and Experimental Therapeutics 289(2), 676-681 (1999)
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