Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
Targets for Drug Metabolite
Products for Drug Metabolite
- Cat.No. Nom du produit Informations
-
GC45208
α-hydroxy Metoprolol
α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol.
-
GC40480
α-Phenyl-α-(2-pyridyl)acetonitrile
NSC 16276, 2-Pyridylphenylacetonitrile
α-Phenyl-α-(2-pyridyl)thioacetamide, also known as antigastrin and SC-15396, is an inhibitor of gastric acid secretion. -
GC41661
(±)-4-hydroxy Propranolol β-D-Glucuronide
(±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol, which is a metabolite of propranolol.
-
GC46284
(±)-Cotinine-d3
An internal standard for the quantification of cotinine
-
GC41671
(±)-Equol 4'-sulfate (sodium salt)
R,S-Equol 4'-Sulfate
(±)-Equol 4'-sulfate is a gut-mediated phase II metabolite of the isoflavonoid phytoestrogen (±)-equol.
-
GC41315
(±)-Ketoprofen Glucuronide
rac-Ketoprofen Acyl-β-D-glucuronide, (R,S)-Ketoprofen Glucuronide
(±)-Ketoprofen glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) ketoprofen.
-
GC49875
(±)-N-desmethyl Venlafaxine (hydrochloride)
Wy 45494
A minor active metabolite of venlafaxine -
GC45252
(-)-Sitagliptin Carbamoyl Glucuronide
(R)-Sitagliptin Carbamoyl Glucuronide
(-)-Sitagliptin carbamoyl glucuronide is a minor phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin. -
GC18622
(2'S)-Nicotine-1-oxide
Nicotine-N-oxide
(2'S)-Nicotine-1-oxide is a metabolite of nicotine . -
GC68509
(25R)-12α-Hydroxyspirost-4-en-3-one
(25R)-12α-Hydroxyspirost-4-en-3-one est un métabolite secondaire produit par l'action de Nocardia globerula sur l'Hécogénine.
-
GC41694
(3S)-hydroxy Quinidine
(3S)-hydroxy Quinidine is an active quinidine metabolite.
-
GC60399
(E)-10-Hydroxynortriptyline
10(E)-hydroxy Nortriptyline
La (E)-10-hydroxynortriptyline (E-10-OH-NT) est un métabolite de la nortriptyline. -
GC91418
(E)-KPT-330
KTP-330; trans Selinexor
(E)-KPT-330 est un métabolite de l'inhibiteur d'exportine 1 (XPO1/CRM1) selinexor.
-
GC40286
(E,Z)-2-propyl-2-Pentenoic Acid
2-propyl-2-Pentenoate, 2-propylpenten-2-oic Acid, 2-ene-VPA
(E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity. -
GC49189
(E/Z)-4-hydroxy Tamoxifen-d5
Afimoxifene-d5, 4-OHT-d5
An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen -
GC62737
(R)-(-)-O-Desmethyl Venlafaxine D6
-
GC41722
(R,S)-Carvedilol Glucuronide
(R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide.
-
GC60410
(Rac)-3′-Hydroxy simvastatin
(Rac)-3′ ; - L'hydroxysimvastatine est un métabolite de la simvastatine.
-
GC41736
(S)-Dibutyl 3-Hydroxybutyl Phosphate
(S)TBPOH
Dibutyl 3-hydroxybutyl phosphate is a compound produced from the metabolism of the organophosphorus solvent, tributyl phosphate (TBP). -
GC40145
(S)-Laudanosine
(+)-Laudanosine, L-Laudanosine, L-(+)-Laudanosine, NSC 35045
(S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium. -
GC49179
(S)-O-Desmethyl Naproxen
(S)-6-Desmethyl Naproxen
A metabolite of (S)-naproxen -
GC60419
(S)-O-Desmethyl Venlafaxine N-Oxide
(S)-O-Desmethyl Venlafaxine N-Oxide est un N-oxyde de (S)-O-Desmethyl Venlafaxine.
-
GC60427
(Z)-10-Hydroxynortriptyline
10(Z)-hydroxy Nortriptyline
La (Z)-10-hydroxynortriptyline est un métabolite de la nortriptyline. -
GC67761
(Z)-10-Hydroxynortriptyline-d3
-
GC18596
(±)-2-propyl-4-Pentenoic Acid
2-Allylpentanoic Acid, 4-ene VPA
L'acide (±)-2-propyl-4-penténoÏque (4-en-VPA) est un métabolite toxique majeur de l'acide valproÏque. -
GC41995
1'-hydroxy Midazolam
Ro 21-6347
Principal métabolite de l'anesthésique, le midazolam.
-
GC41837
1,3,7-Trimethyluric Acid
8-oxo Caffeine, NSC 11259
L'acide 1,3,7-triméthylurique est le métabolite de la caféine. Le rapport métabolique de l'acide 1,3,7-triméthylurique À la caféine peut être évalué en tant que biomarqueur pour décrire la variabilité de l'activité du CYP3A dans une cohorte. -
GC46387
1,3,7-Trimethyluric Acid-d9
TMU-d9, 8-oxo Caffeine-d9
An internal standard for the quantification of 1,3,7-trimethyluric acid -
GC49294
1-(4-Chlorobenzhydryl)piperazine
N-(p-Chlorobenzhydryl)-piperazine, Norchlorcyclizine, NSC 86164
An inactive metabolite of meclizine and chlorcyclizine -
GC49366
1-Salicylate Glucuronide
Salicyl Phenolic Glucuronide, Salicylic Acid Phenolic Glucuronide
A metabolite of salicylic acid and aspirin -
GC49820
10,11-dihydro-10,11-dihydroxy Carbamazepine
10,11-dihydro-10,11-dihydroxy CBZ, CBZ-diol, Dihydroxycarbazepine, Dihydroxycarbamazepine
A metabolite of carbamazepine and oxcarbazepine -
GC66057
10,11-Dihydrocarbamazepine
La 10,11-dihydrocarbamazépine est le métabolite actif de l'oxcarbazépine. La 10,11-dihydrocarbamazépine est également un intermédiaire. L'oxcarbazépine est rapidement et presque complètement convertie en 10,11-dihydrocarbamazépine avec une efficacité anticonvulsivante probable.
-
GC49118
10-hydroxy Warfarin
A metabolite of (R)-warfarin
-
GC49759
13C17-Mycophenolic Acid
13C17-MPA
An internal standard for the quantification of mycophenolic acid -
GC19442
15-Acetyldeoxy Nivalenol
15-Acetyl Vomitoxin, 15-AcDON, Deoxynivalenol 15-acetate, DON 15-acetate
Le 15-acétyldésoxy nivalénol est un trichothécène hautement toxique présent dans les céréales, et un métabolite du désoxynivalénol, présente une toxicité pour les cellules HepG2. -
GC41937
15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide
15ketoBimatoprost, 17phenyl trinor PGF2α ethyl amide
Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug. -
GC41309
16α-hydroxy Prednisolone
16α-hydroxy Prednisolone est un métabolite stéréosélectif de l'épimère 22(R) du budésonide glucocorticoÏde via les enzymes du cytochrome P450 3A (CYP3A).
-
GC41300
17β-hydroxy Exemestane
17β-hydroxy Exemestane is the primary active metabolite of exemestane.
-
GC46471
17β-hydroxy Exemestane-d3
A neuropeptide with diverse biological activities
-
GC71042
18β-Glycyrrhetyl-3-O-sulfate
18β-Glycyrrhetyl-3-O-sulfate (acide glycyrrhizoïque 3 - O - (sulfate d'hydrogène)) est un puissant inhibiteur de la 11β - hydroxystéroïde déshydrogénase (11β - hsd2) de type 2 avec une CI50 de 0,10 µm en utilisant des microsomes rénaux de rat.
-
GC49823
2′-C-β-Methylguanosine
An active nucleoside metabolite of BMS-986094
-
GC46508
2',2'-Difluoro-2'-deoxyuridine
dFdU
An active metabolite of gemcitabine -
GC49159
2-(1-Piperazinyl)pyrimidine
PmP, 1-PP, 1-(2-Pyrimidyl)piperazine
An α2-AR antagonist and active metabolite of azapirones -
GC49330
2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one (hydrochloride)
A metabolite of mazindol
-
GC52029
2-Aminoflubendazole
Hydrolyzed Flubendazole
Le 2-aminoflubendazole est le métabolite des benzimidazoles. -
GC46539
2-Chloroadenine
6-amino-2-chloropurine, 2-chloro-6-aminopurine, NSC 7362
A heterocyclic building block -
GC40675
2-deoxy-Artemisinin
2-deoxy-Artemisinin is an inactive metabolite of the antimalarial agent artemisinin.
-
GC35090
2-Hydroxy atorvastatin calcium salt
o-hydroxy Atorvastatin, ortho-hydroxy Atorvastatin, BMS 243887-01, PD 152873
Le sel de calcium d'atorvastatine 2-hydroxy est un métabolite hydroxy du sel de calcium d'atorvastatine. -
GC60474
2-Hydroxy atorvastatin lactone
La 2-hydroxy atorvastatine lactone est un métabolite de l'atorvastatine.
-
GC64336
2-Hydroxyemodin
La 2-hydroxyémodine est un métabolite actif de l'émodine dans les microsomes hépatiques.
-
GC62777
2-Methoxy-4-vinylphenol
Le 2-méthoxy-4-vinylphénol (2M4VP), un inhibiteur naturel de la germination, exerce de puissants effets anti-inflammatoires.
-
GC70763
2-NP-AMOZ
2-NP-AMOZ est un dérivé 2-nitrophénylique de l’amoz (un métabolite de l’antibiotique Furaltadone), peut être utilisé pour détecter l’amoz lié aux protéines.
-
GC42189
2-oxo Clopidogrel
2-oxo Clopidogrel is an intermediary metabolite of clopidogrel.
-
GC40968
21-hydroxy Eplerenone
21-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone.
-
GC35079
24, 25-Dihydroxy VD2
Le 24, 25-dihydroxy VD2 est un métabolite hydroxylé de la vitamine D2 ; un analogue synthétique de la vitamine D.
-
GC49365
25-Desacetyl Rifampicin
Desacetylrifampicin
A major active metabolite of rifampicin -
GC62033
3α-Hydroxy pravastatin sodium
3α-Isopravastatin, R-416
3α ; - L'hydroxypravastatine sodique est le principal métabolite de la pravastatine. -
GC41480
3'-hydroxy Lidocaine
m-hydroxy Lidocaine, meta-hydroxy Lidocaine
3'-hydroxy Lidocaine is an active metabolite of lidocaine formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4. -
GC39611
3'-Hydroxy Repaglinide
Le 3'-hydroxyrépaglinide est l'un des principaux métabolites CYP2C8 du répaglinide.
-
GC60500
3'-Hydroxy Repaglinide D5
Le 3'-hydroxy répaglinide D5 est le 3'-hydroxy répaglinide marqué au deutérium.
-
GC68082
3,4,5-Trimethoxyphenylacetic acid
-
GC39841
3,4-Dehydro Cilostazol
OPC 13015
Le 3,4-déhydro cilostazol (OPC-13015) est un métabolite actif du cilostazol. -
GC52324
3-(3-Hydroxyphenyl)propionic Acid sulfate
3-HPPA sulfate
A metabolite of certain phenols and glycosides -
GC42198
3-(4-Chlorophenyl)-4-hydroxybutyric Acid (sodium salt)
γ-Hydroxybaclofen
An inactive metabolite of baclofen -
GC46583
3-Amino-2,6-Piperidinedione
α-Aminoglutarimide, 3-Aminoglutarimide, Glutamimide
An active metabolite of (±)-thalidomide -
GC67902
3-Amino-2-oxazolidinone-d4
AOZ-d4
-
GC42274
3-hydroxy Darifenacin
UK 148993
3-hydroxy Darifenacin is a metabolite of darifenacin. -
GC42275
3-hydroxy Desloratidine
SCH 45581
3-hydroxy Desloratidine is a major metabolite of desloratadine , a tricyclic antagonist of the histamine H1 receptor. -
GC41565
3-hydroxy Medetomidine
3-OH Medetomidine, Medetomidine metabolite MIII
3-hydroxy Medetomidine is a metabolite of the α2-adrenergic receptor agonist medetomidine. -
GC90789
3-hydroxy Xylazine
Un métabolite de la xylazine.
-
GC48457
3-keto Fusidic Acid
3-keto FA, 3-Oxofusidic Acid
An active metabolite of fusidic acid -
GC33738
3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride)
3-Methoxy-4-hydroxyphenethylamine, 3-Methoxy-p-hydroxyphenethylamine, 3-O-methyl Dopamine
Le chlorhydrate de 3-méthoxytyramine (chlorhydrate de 3-O-méthyl dopamine) est un métabolite inactif de la dopamine qui peut activer le récepteur 1 associé aux traces d'amines (TAAR1). -
GC68324
3-Methoxytyramine-d4 hydrochloride
3-O-methyl Dopamine-d4 hydrochloride
-
GC49869
3-Methoxytyrosine
DL-3-O-Methyldopa, NSC 122476, 3-methoxy-DL-Tyrosine
An active metabolite of L-DOPA -
GC42307
3-O-methyl-L-DOPA (hydrate)
3-O-methyl-3,4-Dihydroxyphenylalanine, 3-methoxy DOPA, 3-OMD
3-O-methyl-L-DOPA is a metabolite of L-DOPA, produced by the activity of catechol O-methyltransferase. -
GC49367
4’-hydroxy Atomoxetine Glucuronide (hydrate)
A metabolite of atomoxetine
-
GC49252
4’-hydroxy Trazodone
A metabolite of trazodone
-
GC18527
4'-hydroxy Flurbiprofen
A major active metabolite of flurbiprofen
-
GC49752
4,5-Desisopropylidene Topiramate
4,5-Desisopropylidene TPM
An inactive metabolite of topiramate -
GC49337
4-Acetamidobenzenesulfonamide
APAS, N-Acetyl p-Aminobenzene Sulfonamide, N4-Acetyl Sulfanilamide, N-Acetylsulfanilamide, NSC 217, NSC 406839
A metabolite of asulam and sulfanilamide -
GC42370
4-desmethoxy Omeprazole
4-desmethoxy OMEP, 4-desmethoxy OMP, 4-desmethoxy OMZ, Esomeprazol Magnesium Impurity B, Omeprazole EP Impurity B
Le 4-desméthoxy oméprazole est le métabolite actif de l'oméprazole. -
GC18194
4-Epidoxycycline
4-ED
4-Epidoxycycline is the 4-epimer hepatic metabolite of the antibiotic doxycycline . -
GC42401
4-hydroperoxy Cyclophosphamide
4-OOH-CY
4-hydroperoxy Cyclophosphamide, métabolite actif du cyclophosphamide, peut réticuler l'ADN et induire l'apoptose des cellules T indépendamment de l'activation du récepteur de la caspase. Il active également la voie de la mort mitochondriale par la production d'espèces réactives de l'oxygène (ROS). -
GC42402
4-hydroxy (S)-Duloxetine β-D-Glucuronide (sodium salt)
LY550408
4-hydroxy (S)-Duloxetine β-D-glucuronide is an inactive metabolite of the serotonin and norepinephrine reuptake inhibitor (S)-duloxetine. -
GC42405
4-hydroxy Atorvastatin (calcium salt)
p-hydroxy Atorvastatin, para-hydroxy Atorvastatin
4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. -
GC18425
4-hydroxy Atorvastatin lactone
p-hydroxy Atorvastatin lactone, para-hydroxy Atorvastatin lactone
4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.
-
GC42407
4-hydroxy Diclofenac
Le 4-hydroxy diclofénac est un métabolite actif du diclofénac par voie orale par le cytochrome P450 2C9 (CYP2C9).
-
GC42409
4-hydroxy Nebivolol (hydrochloride)
4-hydroxy Nebivolol is a major metabolite of nebivolol.
-
GC49575
4-hydroxy Omeprazole sulfide
4-hydroxy OMEP sulfide, 4-hydroxy OMP sulfide, 4-hydroxy OMZ sulfide
A metabolite of omeprazole -
GC40879
4-hydroxy Solifenacin N-oxide
4-hydroxy Solifenacin N-oxide is an N-oxide form of 4-hydroxy solifenacin, the major metabolite of solifenacin .
-
GC42415
4-hydroxy Valsartan
CGP 71580, Valeryl 4-hydroxy Valsartan
4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan. -
GC18417
4-hydroxy Xylazine
p-hydroxy Xylazine, para-hydroxy Xylazine
4-hydroxy Xylazine est un métabolite de la xylazine.
-
GC90790
4-hydroxy Xylazine O-Glucuronide (lithium salt)
Un métabolite de la xylazine
-
GC91641
4-Hydroxy-1-(2-phenylethyl)piperidine
4-Hydroxy-1-(2-phenylethyl)piperidine is a building block that has been used in the synthesis of ligands of the muscarinic acetylcholine receptor (mAChR) or sigma non-opioid intracellular receptor 1 (σ1 receptor).
-
GC60517
4-Hydroxyatomoxetine
La 4-hydroxyatomoxétine est un métabolite actif de l'atomoxétine.
-
GC39307
4-Methylamino antipyrine
La 4-méthylamino antipyrine est un métabolite actif du métamizole.
-
GC60523
4-Methylamino antipyrine hydrochloride
Metamizole Impurity C
Le chlorhydrate de 4-méthylamino antipyrine est un métabolite actif du métamizole. -
GC49127
4-oxo Cyclophosphamide
4-keto CP, 4-keto Cyclophosphamide, NSC 139488, 4-oxo CP
An inactive metabolite of cyclophosphamide -
GC41399
5α-dihydro Levonorgestrel
5α-DHLNG
5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel. -
GC18582
5'-hydroxy Meloxicam
A metabolite of meloxicam