Src
Src (proto-oncogene tyrosine-protein kinase) is a non-receptor protein tyrosine kinase family including 9 members and promotes survival, angiogenesis, proliferation and invasion pathways.
Products Related to Src(113)
- GC79423IL13Rα2 D1CAS: 2319573-67-4Purity: >99.00%
IL13Rα2 D1 is an effective IL-13/IL13Rα2 signaling axis inhibitor.
- GC79481HPK1-IN-2 TFAPurity: >99.50%
HPK1-IN-2 TFA is an orally active HPK1 inhibitor ( IC 50 < 0.05 µM) with antitumor activity.
- GC81297DFCI-002-06CAS: 3092208-36-8Purity: >98%
DFCI-002-06 is an orally active dual-target HCK/BTK PROTAC degrader with DC₅₀ values for HCK and BTK of 1.3 and 4.5 nM respectively.
- GC81303PROTAC AR Degrader-12Purity: >98.50%
PROTAC AR Degrader-12 is a highly efficient PROTAC targeting AR coactivator binding site (AR-CBS).
- GC81305Tyrosine kinase-IN-11CAS: 3031972-21-8Purity: >98.50%
Tyrosine kinase-IN-11 (Compound 4b) is a tyrosine kinase inhibitor.
- GC81320PapaverolineCAS: 574-77-6Purity: >98%
Papaveroline is a Fyn tyrosine kinase inhibitor, Na +,K + -ATPase inhibitor with an IC 50 of 0.20 mM, Mg 2+ -ATPase inhibitor, K + -activated pNPPase inhibitor with an IC 50 of 1.51 mM, and apoptosis inducer [1] [2] [3] . Papaveroline binds to the active site of Fyn tyrosine kinase and forms stable interactions with pocket amino acid residues [1] . Papaveroline induces cell apoptosis, produces pycnotic and fragmented cell nuclei, and does not reduce intracellular ATP levels [3] . Papaveroline is a dopamine-derived neurotoxin candidate associated with the pathogenesis of Parkinson's disease [3] . Papaveroline can be used in the research of Alzheimer's disease and Parkinson's disease [3] .
- GC81327Papaveroline hydrochlorideCAS: 28362-21-2Purity: >99.00%
Papaveroline hydrochloride is an orally active Fyn tyrosine kinase inhibitor.
- GC81842Lck Inhibitor III free baseCAS: 918870-44-7Purity: >98.00%
Lck Inhibitor III free base is a Lck inhibitor with an IC 50 of 867 nM.
- GC17789A 419259 trihydrochlorideCAS: 1435934-25-0Purity: >98.00%
Un trichlorhydrate 419259 est un inhibiteur des kinases de la famille Src avec des CI50 de 9 nM, 3 nM et 3 nM pour Src, Lck et Lyn, respectivement.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC79423 | IL13Rα2 D1 | 2319573-67-4 | >99.00% | |
IL13Rα2 D1 is an effective IL-13/IL13Rα2 signaling axis inhibitor. | ||||
| GC79481 | HPK1-IN-2 TFA | - | >99.50% | |
HPK1-IN-2 TFA is an orally active HPK1 inhibitor ( IC 50 < 0.05 µM) with antitumor activity. | ||||
| GC79875 | TL02-59-d 5 | - | >98.00% | |
TL02-59 -d 5 is the deuterium labeled TL02-59. | ||||
| GC80874 | ARN25699 | - | >98% | |
ARN25699 is a kinase inhibitor with an IC 50 of 5.5 nM against GSK-3β, 2.2 nM against FYN-α, and 242.3 nM against DYRK1A, and it exhibits oral bioavailability. | ||||
| GC81297 | DFCI-002-06 | 3092208-36-8 | >98% | |
DFCI-002-06 is an orally active dual-target HCK/BTK PROTAC degrader with DC₅₀ values for HCK and BTK of 1.3 and 4.5 nM respectively. | ||||
| GC81303 | PROTAC AR Degrader-12 | - | >98.50% | |
PROTAC AR Degrader-12 is a highly efficient PROTAC targeting AR coactivator binding site (AR-CBS). | ||||
| GC81305 | Tyrosine kinase-IN-11 | 3031972-21-8 | >98.50% | |
Tyrosine kinase-IN-11 (Compound 4b) is a tyrosine kinase inhibitor. | ||||
| GC81315 | Lck-IN-5 | 1356734-45-6 | >98.00% | |
Lck-IN-5 (example C10) is a potent and selective lymphocyte-specific protein tyrosine kinase ( LCK ) inhibitor. | ||||
| GC81320 | Papaveroline | 574-77-6 | >98% | |
Papaveroline is a Fyn tyrosine kinase inhibitor, Na +,K + -ATPase inhibitor with an IC 50 of 0.20 mM, Mg 2+ -ATPase inhibitor, K + -activated pNPPase inhibitor with an IC 50 of 1.51 mM, and apoptosis inducer [1] [2] [3] . Papaveroline binds to the active site of Fyn tyrosine kinase and forms stable interactions with pocket amino acid residues [1] . Papaveroline induces cell apoptosis, produces pycnotic and fragmented cell nuclei, and does not reduce intracellular ATP levels [3] . Papaveroline is a dopamine-derived neurotoxin candidate associated with the pathogenesis of Parkinson's disease [3] . Papaveroline can be used in the research of Alzheimer's disease and Parkinson's disease [3] . | ||||
| GC81327 | Papaveroline hydrochloride | 28362-21-2 | >99.00% | |
Papaveroline hydrochloride is an orally active Fyn tyrosine kinase inhibitor. | ||||
| GC81443 | E8431 | 2419580-01-9 | >97.00% | |
E8431 is a DCSTAMP antagonist with an IC 50 value of 775.8 nM for osteoclastogenesis. | ||||
| GC81842 | Lck Inhibitor III free base | 918870-44-7 | >98.00% | |
Lck Inhibitor III free base is a Lck inhibitor with an IC 50 of 867 nM. | ||||
| GN10633 | Scutellarein | 529-53-3 | >99.50% | |
| GC11696 | 1-NM-PP1 | 221244-14-0 | >99.50% | |
1-NM-PP1, un analogue de PP1 perméable aux cellules, est un puissant inhibiteur des kinases de la famille Src avec des IC50 de 4,3 nM et 3,2 nM pour v-Src-as1 et c-Fyn-as1, respectivement. | ||||
| GC14288 | KX2-391 | 897016-82-9 | >99.00% | |
KX2-391 (KX2-391) est un inhibiteur de Src qui cible le site du substrat peptidique de Src, avec un GI50 de 9 À 60 nM dans les lignées cellulaires cancéreuses. | ||||
| GC17789 | A 419259 trihydrochloride | 1435934-25-0 | >98.00% | |
Un trichlorhydrate 419259 est un inhibiteur des kinases de la famille Src avec des CI50 de 9 nM, 3 nM et 3 nM pour Src, Lck et Lyn, respectivement. | ||||
| GC10523 | KX1-004 | 518058-84-9 | >99.50% | |
KX1-004 est un inhibiteur puissant et non compétitif de Src-PTK avec une IC50 de 40 μM. | ||||