Fumitremorgin B (Synonyms: Lanosulin)

Fumitremorgin B is a mycotoxin originally isolated from A. fumigatus.^1,2 It induces tremors in and is lethal to mice (LD₅₀ = 5.4 mg/kg, i.v.). It is also toxic to brine shrimp (LC₅₀ = 13.6 μg/ml).³ Fumitremorgin B is active against the phytopathogenic fungi B. cinerea, A. solani, A. alternata, C. gloeosporioides, F. solani, F. oxysporum, and G. saubinettii (MICs = 6.25-100 μg/ml). It has antifeedant activity against armyworm (M. separata) larvae when applied to fresh wheat leaves. Fumitremorgin B inhibits the proliferation of U937 and PC3 cells (IC₅₀s = 14.12 and 43.36 μM, respectively).⁴

1.Yamazaki, M., Suzuki, S., and Miyaki, K.Tremorgenic toxins from Aspergillus fumigatus FresChem. Pharm. Bull. (Tokyo)19(8)1739-1740(1971) 2.Yamazaki, M., and Suzuki, S.Toxicology of tremorgenic mycotoxins, fumitremorgin A and BDev. Toxicol. Environ. Sci.12273-282(1986) 3.Li, X.-J., Zhang, Q., Zhang, A.-L., et al.Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activitiesJ. Agric. Food Chem.60(13)3424-3431(2012) 4.Wang, Y., Li, Z.-L., Bai, J., et al.2,5-diketopiperazines from the marine-derived fungus Aspergillus fumigatus YK-7Chem. Biodivers.9(2)85-93(2012)