H-Glu(Tyr-OH)-OH |
Catalog No.GA22366
One-Click Copy Product Info
|
H-Glu(Tyr-OH)-OH is a dipeptide composed of glutamic acid (Glu) and tyrosine (Tyr). Its chemical name is L-glutamyl-L-tyrosine, with the molecular formula C₁₄H₁₈N₂O₆ and a molecular weight of approximately 310.3. H-Glu(Tyr-OH)-OH is a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV) (IC₅₀ = 6.77mM) and may have potential for the treatment of type II diabetes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 7432-23-7
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
H-Glu(Tyr-OH)-OH is a dipeptide composed of glutamic acid (Glu) and tyrosine (Tyr). Its chemical name is L-glutamyl-L-tyrosine, with the molecular formula C₁₄H₁₈N₂O₆ and a molecular weight of approximately 310.3. H-Glu(Tyr-OH)-OH is a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV) (IC₅₀ = 6.77 mM) and may have potential for the treatment of type II diabetes[1]. The tyrosine portion of H-Glu(Tyr-OH)-OH contains a phenolic hydroxyl group, which may confer antioxidant properties, allowing it to react with free radicals and thereby reduce oxidative damage[2]. Glutamic acid and tyrosine are important precursors of neurotransmitters, and the hydrolysis products of H-Glu(Tyr-OH)-OH may be involved in the transmission and modulation of nerve signals[3]. Some studies suggest that in Alzheimer's disease and Parkinson's disease, the metabolism of glutamine and tyrosine is abnormal, and the levels of H-Glu(Tyr-OH)-OH and its related metabolites may also change[4]。
References:
[1] Juan Yang, Dongxiao Sun-Waterhouse, Chun Cui, et al. γ‐Glu‐Met synthesised using a bacterial glutaminase as a potential inhibitor of dipeptidyl peptidase IV[J]. International Journal of Food Science & Technology, 2018, 53(5): 1166-1175.
[2] Jeffrey RF, MacDonald TM, Lee MR. A comparison of the renal actions of gamma-L-glutamyl-L-dopa and gamma-L-glutamyl-L-tyrosine in normal man. Clin Sci (Lond). 1988 Jan;74(1):37-40.
[3] Nemeroff CB. The role of neuropeptides in the pathophysiology of affective disorders. Clin Neuropharmacol. 1992;15 Suppl 1 Pt A:6A-7A.
[4] Liu S, Zhong H, Zhu J, et al. Identification of blood metabolites associated with risk of Alzheimer's disease by integrating genomics and metabolomics data. Mol Psychiatry. 2024 Apr;29(4):1153-1162.
| Cas No. | 7432-23-7 | SDF | |
| Formula | C14H18N2O6 | M.Wt | 310.31 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2226 mL | 16.1129 mL | 32.2258 mL |
| 5 mM | 644.5 μL | 3.2226 mL | 6.4452 mL |
| 10 mM | 322.3 μL | 1.6113 mL | 3.2226 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)