1,4-Diaminobutane dihydrochloride is an endogenous metabolite, acts as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI) [1]. 1,4-Diaminobutane dihydrochloride is an important source of GABA[2]. Human Endogenous Metabolite[1]
1,4-Diaminobutane is an important source of GABA in the postnatal rat subventricular zone. GABA synthesis from an alternative pathway uses 1,4-Butanediamine as a precursor[2].
[1]. Hauschild MZ. Putrescine (1,4-diaminobutane) as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). Ecotoxicol Environ Saf. 1993 Oct;26(2):228-47. [2]. Sequerra EB, et al. Putrescine as an important source of GABA in the postnatal rat subventricular zone. Neuroscience. 2007 May 11;146(2):489-93.