GLPBio

6-Thioinosine

Catalog No.: GC35171Purity:>98.50%
COASDSData Sheet
6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα.

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6-Thioinosine
Cas No.: 574-25-4
10mM (in 1mL DMSO)In Stock
$50.00
1
5mgIn Stock
$45.00
1
10mgIn Stock
$72.00
1
25mgIn Stock
$120.00
1
50mgIn Stock
$162.00
1
100mgIn Stock
$225.00
1
200mgIn Stock
$335.00
1
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Description

6-?Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα[1][2].

[1]. Lee J, et al. Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR gamma through JNK-dependent upregulation of iNOS. Cell Mol Life Sci. 2010 Feb;67(3):467-81. [2]. Neubert D, et al. Interference of 6-mercaptopurine riboside, 6-methylmercaptopurine riboside and azathioprine with the morphogenetic differentiation of mouse extremities in vivo and in organ culture. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):93-105.

Product Documents

Purity:>98.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
574-25-4
SMILES
S=C1NC=NC2=C1N=CN2C3[C@@H]([C@@H]([C@@H](CO)O3)O)O
Molecular Formula
C10H12N4O4S
Molecular Weight
284.29
Solubility
DMSO: 50 mg/mL (175.88 mM)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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