ALK inhibitor 1 is a novel and selective inhibitor for the ALK kinase.
[1]. A Dose Finding Study With Oral LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase (ALK).
ALK inhibitor 1
Catalog No.: GC35287Purity:>99.50%
ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor. ALK inhibitor 1 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 761436-81-1
10mM (in 1mL DMSO)In Stock
$137.00
1
1mgIn Stock
$45.00
1
5mgIn Stock
$111.00
1
10mgIn Stock
$170.00
1
25mgIn Stock
$280.00
1
50mgIn Stock
$399.00
1
100mgIn Stock
$539.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $137.00 | In Stock | 1 | |
| 1mg | $45.00 | In Stock | 1 | |
| 5mg | $111.00 | In Stock | 1 | |
| 10mg | $170.00 | In Stock | 1 | |
| 25mg | $280.00 | In Stock | 1 | |
| 50mg | $399.00 | In Stock | 1 | |
| 100mg | $539.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Product Documents
Purity:>99.50%Appearance:A solid
Chemical Properties
CAS No.
761436-81-1
SMILES
O=S(C1=C(NC2=C(Br)C=NC(NC3=C(OC)C=C(N4CCN(C)CC4)C=C3)=N2)C=CC=C1)(NC)=O
Molecular Formula
C23H28BrN7O3S
Molecular Weight
562.48
Solubility
DMSO: ≥ 100 mg/mL (177.78 mM); Water: < 0.1 mg/mL (insoluble)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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