GLPBio

DMT1 blocker 2

Catalog No.: GC35886Purity:>99.00%
COASDSData Sheet
DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM.

Products are for research use only. Not for human use. We do not sell to patients.

DMT1 blocker 2
Cas No.: 1062648-63-8
10mM (in 1mL DMSO)In Stock
$248.00
1
5mgIn Stock
$225.00
1
10mgIn Stock
$405.00
1
10mgIn Stock
$405.00
1
25mgIn Stock
$765.00
1
50mgIn Stock
$1,215.00
1
100mgIn Stock
$1,755.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

DMT1 blocker 2, Compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 of 0.83 μM, is expected to block iron uptake by enterocytes in vivo[1].

IC50: 0.83 μM (DMT1 blocker 2)[1]

[1]. Cadieux JA, et al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett. 2012 Jan 1;22(1):90-5.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1062648-63-8
SMILES
OC1=C2C3=C(C=CC=C3)CCC2=NN1C4=NC=CC=C4
Molecular Formula
C16H13N3O
Molecular Weight
263.29
Solubility
DMSO : 50 mg/mL (189.90 mM; Need ultrasonic)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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