GLPBio

E3 ligase Ligand-Linker Conjugates 39

Catalog No.: GC35946Purity:>98%Synonyms: E3 ligase Ligand-Linker Conjugates 39
COASDSData Sheet
E3 ligase Ligand-Linker Conjugates 39 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 39 can be used to design SNIPERs.

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E3 ligase Ligand-Linker Conjugates 39
Cas No.: 2113688-20-1
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Citations

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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

E3 ligase Ligand-Linker Conjugates 39 incorporates a cIAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 39 can be used to design PROTAC degrader[1]. cIAP1

[1]. Itoh Y, et al. Design, synthesis and biological evaluation of nuclear receptor-degradation inducers. Bioorg Med Chem. 2011 Nov 15;19(22):6768-78.

Chemical Properties

CAS No.
2113688-20-1
Synonyms
E3 ligase Ligand-Linker Conjugates 39
SMILES
C[C@H](N(C(OC(C)(C)C)=O)C)C(N[C@@H](C1CCCCC1)C(N(CCC2)[C@@H]2C3=NC(C(C4=CC=CC(OCCOCCOCCN)=C4)=O)=CS3)=O)=O
Molecular Formula
C37H55N5O8S
Molecular Weight
729.93
Solubility
Soluble in DMSO
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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