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TBCA (Synonyms: Casein Kinase II Inhibitor III,Tetrabromocinnamic Acid)

Catalog No.GC14181

CK2 inhibitor

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TBCA Chemical Structure

Cas No.: 934358-00-6

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1mg
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5mg
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10mg
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25mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Tetrabromocinnamic Acid (TBCA) is a new class of specific protein kinase CK2 inhibitors [1].

Protein kinases have been involved in catalyzing the phosphorylation of serine, threonine and tyrosine residues in protein substrates that play dominant roles in controlling nearly all cellular functions. The Ser/Thr-specific protein kinase CK2 has been implicated in signal transduction, gene expression, DNA repair, RNA and protein synthesis. CK2 is invariably elevated in a wide spectrum of tumours [1].

In vitro: TBCA was a selective, cell-permeable inhibitor of CK2 with an IC50 of 0.11 μM. The Ki value was 77 nM. TBCA showed minimal effect on a panel of 28 other kinases. TBCA induced cell death in Jurkat adult T cell leukemia cells with an DC50 of 7.7 μM [1]. TBCA dose-dependently inhibited platelet aggregation and secretion induced by various agonists including 2-MeSADP, AYPGKF, SFLLRN, and CRP [2]. TBCA also significantly inhibited agonist-induced thromboxane A2 (TxA2) generation and ERK phosphorylation. TBCA significantly inhibited platelet spreading on immobilized fibrinogen surface and clot retraction mediated by integrin αIIbβ3 signaling [2].

References:
[1] Pagano M A, Poletto G, Di Maira G, et al.  Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors[J]. Chembiochem, 2007, 8(1): 129-139.
[2] Ryu S Y, Kim S.  Evaluation of CK2 inhibitor (E)-3-(2, 3, 4, 5-tetrabromophenyl) acrylic acid (TBCA) in regulation of platelet function[J]. European journal of pharmacology, 2013, 720(1): 391-400.

Chemical Properties

Cas No. 934358-00-6 SDF
Synonyms Casein Kinase II Inhibitor III,Tetrabromocinnamic Acid
Chemical Name (2E)-3-(2,3,4,5-tetrabromophenyl)-2-propenoic acid
Canonical SMILES BrC1=C(Br)C(Br)=C(Br)C=C1/C=C/C(O)=O
Formula C9H4Br4O2 M.Wt 463.7
Solubility ≤1mg/ml in ethanol;2mg/ml in DMSO;5mg/ml in dimethyl formamide Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.1566 mL 10.7828 mL 21.5657 mL
5 mM 0.4313 mL 2.1566 mL 4.3131 mL
10 mM 0.2157 mL 1.0783 mL 2.1566 mL
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Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 17 reference(s) in Google Scholar.)

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