HG6-64-1 is a potent and selective B-Raf inhibitor extracted from patent WO 2011090738 A2, example 9 (XI-1); has a IC50 of 0.09 μM on B-raf V600E transformed Ba/F3 cells. B-RafV600E|0.09 μM (IC50, in Ba/F3 cells)
[1]. WO 2011090738 A2
HG6-64-1
Catalog No.: GC36223Purity:>98.00%Synonyms: HMSL 10017-101-1
HG6-64-1 is a potent and selective B-Raf inhibitor extracted from patent WO 2011090738 A2, example 9 (XI-1); has a IC50 of 0.09 μM on B-raf V600E transformed Ba/F3 cells.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1315329-43-1
10mM (in 1mL DMSO)In Stock
$112.00
1
5mgIn Stock
$88.00
1
10mgIn Stock
$131.00
1
25mgIn Stock
$225.00
1
50mgIn Stock
$360.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $112.00 | In Stock | 1 | |
| 5mg | $88.00 | In Stock | 1 | |
| 10mg | $131.00 | In Stock | 1 | |
| 25mg | $225.00 | In Stock | 1 | |
| 50mg | $360.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
1315329-43-1
Synonyms
HMSL 10017-101-1
SMILES
O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(/C=C/C4=CN=C(NC=C5)C5=C4OC)=C3
Molecular Formula
C32H34F3N5O2
Molecular Weight
577.64
Solubility
DMSO: ≥ 100 mg/mL (173.12 mM); Water: < 0.1 mg/mL (insoluble)
Storage
4°C, protect from light, stored under nitrogen
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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