Soyasapogenol A is a triterpenoid compound isolated from the roots of Abrus cantoniensis that exhibits anti-inflammatory, anti-cancer, hepatoprotective, and anti-HSV-1 activities. Soyasapogenol A can be used in the research of tumors and immune inflammatory diseases[1][2][3].
In vitro, treatment with Soyasapogenol A at 10µM for 11 days caused a 68% reduction in MDA-MB-231 cell proliferation, whereas it stimulated a 2.4-fold increase in MCF-7 cell proliferation[4]. Treatment with Soyasapogenol A for 24h increased pS2 mRNA expression in MCF-7 cells by 3.4-fold at 0.1µM and by 5.5-fold at 1µM[4]. Treatment with Soyasapogenol A (0-0.5mg/mL) for 24-72h inhibited the proliferation of Hep-G2 cells, with an LC₅₀ of 0.052mg/mL, and induced cell cycle arrest and apoptosis[1].
In vivo, Soyasapogenol A was orally administered at a dose of 15mg/kg twice weekly for 6 weeks in SKOV-3 xenograft mice, demonstrating a potent and significant reduction in the growth of subcutaneous xenografts by more than 55% and lung metastases by more than 60%[5].
References:
[1] Zhang W, et al. Effect of soyasapogenol A and soyasapogenol B concentrated extracts on HEP-G2 cell proliferation and apoptosis. J Agric Food Chem. 2008 Apr 23;56(8):2603-8.
[2] Kuzuhara H, et al. Protective effects of soyasapogenol A on liver injury mediated by immune response in a concanavalin A-induced hepatitis model. Eur J Pharmacol. 2000 Mar 10;391(1-2):175-81.
[3] Guang C, et al. Biological functionality of soyasaponins and soyasapogenols. J Agric Food Chem. 2014 Aug 20;62(33):8247-55.
[4] Rowlands JC, Berhow MA, Badger TM. Estrogenic and antiproliferative properties of soy sapogenols in human breast cancer cells in vitro. Food Chem Toxicol. 2002;40(12):1767-1774.
[5]Omar A, Kalra RS, Putri J, Elwakeel A, Kaul SC, Wadhwa R. Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells. Sci Rep. 2020;10(1):6323.