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Home >> Signaling Pathways >> Apoptosis >> Other Apoptosis

Other Apoptosis

Products for  Other Apoptosis

  1. Cat.No. Product Name Information
  2. GC45213 α-NETA Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. α-NETA Chemical Structure
  3. GC46008 (±)-Thalidomide-d4

    N-Phthaloylglutamimide-d4

     An internal standard for the quantification of (±)-thalidomide (±)-Thalidomide-d4 Chemical Structure
  4. GC45256 (+)-ar-Turmerone

    (S)(+)arTurmerone

     (+)-ar-Turmerone is an aromatic compound from the rhizomes of C. (+)-ar-Turmerone Chemical Structure
  5. GC41345 (-)-α-Bisabolol

    DL-α-Bisabolol

     (-)-α-Bisabolol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. (-)-α-Bisabolol Chemical Structure
  6. GC40698 (-)-Perillyl Alcohol

    (L)-Perillyl Alcohol, (S)-Perillic Alcohol, (S)-(-)-Perillyl Alcohol

     (-)-Perillyl Alcohol is a monoterpene found in lavender, inhibits farnesylation of Ras, upregulates the mannose-6-phosphate receptor and induces apoptosis. Anti-cancer activity. (-)-Perillyl Alcohol Chemical Structure
  7. GC34965 (20S)-Protopanaxatriol

    20(S)-APPT, 20(S)-PPT

     An active ginsenoside metabolite (20S)-Protopanaxatriol Chemical Structure
  8. GC34981 (E)-Flavokawain A

    Flavokavain A, 4-methoxy Flavokawain B

     (E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. (E)-Flavokawain A Chemical Structure
  9. GC34125 (E)-[6]-Dehydroparadol (E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol, is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells. (E)-[6]-Dehydroparadol Chemical Structure
  10. GN10783 (R) Ginsenoside Rh2 (R) Ginsenoside Rh2 Chemical Structure
  11. GC15104 (R)-(+)-Etomoxir sodium salt

    (R)(+)Etomoxir

     (R)-(+)-Etomoxir sodium salt(Etomoxir) is a small molecule developed for metabolic and cardiovascular disease that exhibits nanomolar potency toward CPT-1a and CPT-1b upon enzymatic conversion to the active inhibitor etomoxiryl CoA (IC50 = 0.01-0.70 µM). (R)-(+)-Etomoxir sodium salt Chemical Structure
  12. GC41716 (R)-CR8 Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-CR8 Chemical Structure
  13. GC19541 (rac)-Antineoplaston A10

    (rac)-Antineoplaston A10 is the racemate of Antineoplaston A10

     (rac)-Antineoplaston A10 Chemical Structure
  14. GC10098 (S)-10-Hydroxycamptothecin

    ChEMBL 273862, NSC 107124

     inhibitor of topoisomerase I (S)-10-Hydroxycamptothecin Chemical Structure
  15. GC11965 (±)-Huperzine A

    Hup A, (-)-Selagine

     A neuroprotective AChE inhibitor (±)-Huperzine A Chemical Structure
  16. GC11988 15-acetoxy Scirpenol

    4-Deacetylanguidin,NSC 267030

     mycotoxin that induce apoptotic cell death 15-acetoxy Scirpenol Chemical Structure
  17. GC11720 17-AAG (KOS953)

    BMS 722782, CP 127374, KOS 953, NSC 330507, Tanespimycin

     17-AAG(Geldanamycin), a natural benzoquinone ansamycin antibiotic, is the first established inhibitor of Hsp90. 17-AAG (KOS953) Chemical Structure
  18. GC13044 17-DMAG (Alvespimycin) HCl 17-DMAG (Alvespimycin) HCl (17-DMAG hydrochloride; KOS-1022; BMS 826476) is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM. 17-DMAG (Alvespimycin) HCl Chemical Structure
  19. GN10065 2-Atractylenolide

    2-Atractylenolide

     2-Atractylenolide Chemical Structure
  20. GC17430 2-Deoxy-D-glucose

    2-DG

     2-Deoxy-D-glucose (2DG), is a glucose analogue, act as competitive glycolytic inhibitor. 2-Deoxy-D-glucose Chemical Structure
  21. GC38318 2-Methoxycinnamaldehyde 2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity. 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9. 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration. 2-Methoxycinnamaldehyde Chemical Structure
  22. GC15084 2-Methoxyestradiol (2-MeOE2)

    2Hydroxyestradiol 2methyl ether, 2ME2, NSC 659853, Panzem

     2-Methoxyestradiol (2-MeOE2/2-Me) is an HIF-1α inhibitor. 2-Methoxyestradiol (2-MeOE2) Chemical Structure
  23. GN10800 20(S)-NotoginsenosideR2 20(S)-NotoginsenosideR2 Chemical Structure
  24. GC35112 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene is a Pterostilbene analogue. 3'-Hydroxypterostilbene inhibits the growth of COLO 205, HCT-116 and HT-29 cells with IC50s of 9.0, 40.2 and 70.9 ?M, respectively. 3'-Hydroxypterostilbene significantly down-regulates PI3K/Akt and MAPKs signaling pathways and effectively inhibits the growth of human colon cancer cells by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene can be used for the research of cancer. 3'-Hydroxypterostilbene Chemical Structure
  25. GC35106 3-Dehydrotrametenolic acid 3-?Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-?Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-?Dehydrotrametenolic acid induces apoptosis and has anticancer activity. 3-Dehydrotrametenolic acid Chemical Structure
  26. GC17394 3-Nitropropionic acid

    β-Nitropropionic Acid, 3-NP, NSC 64266

     3-Nitropropionic acid (β-Nitropropionic acid) is an irreversible inhibitor of succinate dehydrogenase. 3-Nitropropionic acid Chemical Structure
  27. GC35099 3-O-Acetyloleanolic acid

    3-Acetyloleanolic Acid

     3-O-Acetyloleanolic acid (3AOA), an oleanolic acid derivative isolated from the seeds of Vigna sinensis K., induces in cancer and also exhibits anti-angiogenesis activity. 3-O-Acetyloleanolic acid Chemical Structure
  28. GC32767 3BDO

    3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one

     A butyrolactone derivative and autophagy inhibitor 3BDO Chemical Structure
  29. GC42346 4-bromo A23187

    4-Bromocalcimycin

    4-bromo A23187 is a halogenated analog of the highly selective calcium ionophore A23187.

     4-bromo A23187 Chemical Structure
  30. GC30896 4-Hydroxybenzyl alcohol

    NSC 227926, p-Hydroxybenzyl Alcohol

     A phenol with diverse biological activities 4-Hydroxybenzyl alcohol Chemical Structure
  31. GC35138 4-Methyldaphnetin 4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation. 4-Methyldaphnetin Chemical Structure
  32. GC10468 4EGI-1

    eIF4E/eIF4G Interaction Inhibitor

     Competitive eIF4E/eIF4G interaction inhibitor 4EGI-1 Chemical Structure
  33. GC35150 5,7,4'-Trimethoxyflavone 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner. 5,7,4'-Trimethoxyflavone Chemical Structure
  34. GC35147 5-(N,N-Hexamethylene)-amiloride

    HMA

     An amiloride derivative with diverse biological activities 5-(N,N-Hexamethylene)-amiloride Chemical Structure
  35. GC45356 5-Aminolevulinic Acid (hydrochloride)   5-Aminolevulinic Acid (hydrochloride) Chemical Structure
  36. GN10093 6-gingerol 6-gingerol Chemical Structure
  37. GC16853 7,8-Dihydroxyflavone

    7,8-DHF

     7,8-Dihydroxyflavone is a naturally-occurring plant-based flavone and high-affinity tyrosine kinase receptor B (TrkB) agonist with an IC50 value of 0.26μM. 7,8-Dihydroxyflavone Chemical Structure
  38. GC17119 8-Prenylnaringenin

    Flavaprenin,8-PN

     estrogen receptor inhibitor 8-Prenylnaringenin Chemical Structure
  39. GC39152 9-ING-41

    Elraglusib

     9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic drugs. 9-ING-41 Chemical Structure
  40. GN10035 9-Methoxycamptothecin 9-Methoxycamptothecin Chemical Structure
  41. GC11200 A23187

    Calcimycin

    A23187, free acid is a Ca2+ ionophore

     A23187 Chemical Structure
  42. GC35216 AAPK-25 AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM. AAPK-25 Chemical Structure
  43. GC13805 Abacavir Abacavir Chemical Structure
  44. GC35227 ACBI1 ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis. ACBI1 Chemical Structure
  45. GC11786 Acetylcysteine

    N-acetylcysteine; N-acetyl-L-cysteine; NAC; Acetadote

     Acetylcysteine is the N-acetyl derivative of CYSTEINE. Acetylcysteine Chemical Structure
  46. GC17094 Acitretin

    all-trans Acitretin, Ro 10-1670, Ro 10-1670/000

    Metabolite of etretinate

     Acitretin Chemical Structure
  47. GC35242 Actein Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo. Actein Chemical Structure
  48. GC16350 Actinonin

    (-)-Actinonin,Ro 06-1467

    Peptidomimetic antibiotic that inhibits aminopeptidases

     Actinonin Chemical Structure
  49. GC10610 Adapalene

    CD 271

     RARβ and RARγ agonist Adapalene Chemical Structure
  50. GC13959 Adarotene

    ST1926

     An atypical retinoid Adarotene Chemical Structure
  51. GC11892 AEE788 (NVP-AEE788)

    NVP-AEE788

     AEE788 (NVP-AEE788) is an inhibitor of the EGFR and ErbB2 with IC50 values of 2 and 6 nM, respectively. AEE788 (NVP-AEE788) Chemical Structure
  52. GC13168 AG 825

    Tyrphostin AG825

     Selective ErbB2 inhibitor AG 825 Chemical Structure
  53. GC13697 AG-1024

    AGS 200, Tyrphostin AG1024

     AG-1024 is a reversible, competitive and selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 value of 7µM. AG-1024 can inhibit the phosphorylation of insulin receptor (IR) with an IC50 value of 57µM. AG-1024 Chemical Structure
  54. GC17881 AGK 2 AGK2 is a selective SIRT2 inhibitor, with an IC50 of 3.5 µM. AGK2 inhibits SIRT1 and SIRT3 with IC50 of 30 and 91 µM, respectively. AGK 2 Chemical Structure
  55. GC39620 AKOS-22 AKOS-22 Chemical Structure
  56. GC11589 AKT inhibitor VIII A potent inhibitor of Akt1 and Akt2 AKT inhibitor VIII Chemical Structure
  57. GC35275 AKT-IN-3 AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells. AKT-IN-3 Chemical Structure
  58. GC16597 Alda 1

    ALDH2 activator

     Alda 1 Chemical Structure
  59. GC35288 Alkannin

    (-)-Alkannin, NSC 94524

     A naphthoquinone with diverse biological activities Alkannin Chemical Structure
  60. GC32127 Alofanib (RPT835)

    RPT835

     Alofanib (RPT835) (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Alofanib (RPT835) Chemical Structure
  61. GC14314 Aloperine An alkaloid Aloperine Chemical Structure
  62. GC35306 alpha-Mangostin alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. alpha-Mangostin Chemical Structure
  63. GC42776 Amarogentin

    A secoiridoid glycoside with diverse biological activities

     Amarogentin Chemical Structure
  64. GN10484 Amentoflavone

    Didemethyl Ginkgetin, NSC 295677

     Amentoflavone Chemical Structure
  65. GC12051 Amiloride HCl dihydrate Amiloride HCl dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride HCl dihydrate Chemical Structure
  66. GC16391 Amuvatinib (MP-470, HPK 56)

    HPK56, MP470

     A multi-targeted RTK inhibitor Amuvatinib (MP-470, HPK 56) Chemical Structure
  67. GN10045 Angelicin

    Bakuchicin, NSC 404563

     Angelicin Chemical Structure
  68. GC11559 Anisomycin

    Flagecidin, NSC 76712, Wuningmeisu C

     Anisomycin, an antibiotic isolated from Streptomyces griseus, is also a JNK activator. Anisomycin Chemical Structure
  69. GC35361 Antineoplaston A10 Antineoplaston A10, a naturally occurring substance in human body, is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer. Antineoplaston A10 Chemical Structure
  70. GC15586 AP1903

    AP1903

     AP1903 (AP1903) is a dimerizer agent that acts by cross-linking the FKBP domains. AP1903 (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis. AP1903 Chemical Structure
  71. GC35367 APG-115

    AA-115

     APG-115 (APG-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively. APG-115 blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner. APG-115 Chemical Structure
  72. GC16237 Apocynin

    Acetoguaiacone, Acetovanillone, NSC 2146, NSC 209524

     Selective NADPH-oxidase inhibitor Apocynin Chemical Structure
  73. GC14209 Apoptosis Activator 2

    AAII, N-(3,4-dichlorobenzyl) Isatin

     An activator of caspases Apoptosis Activator 2 Chemical Structure
  74. GC14411 Apoptozole

    Apoptosis Activator VII

     inhibitor of heat shock protein 70 (Hsp70) Apoptozole Chemical Structure
  75. GC10420 Apremilast (CC-10004)

    APR, CC-10004

     An orally available PDE4 inhibitor Apremilast (CC-10004) Chemical Structure
  76. GC32692 APTO-253 (LOR-253)

    APTO-253

     APTO-253 is a novel small molecule that exerts potent antitumor activity by inducing Kruppel-like factor 4(KLF4) master transcription factor gene expression, thereby inhibiting cell cycle and leading to programmed cell death. APTO-253 (LOR-253) Chemical Structure
  77. GC14590 AR-42 (OSU-HDAC42)

    HDAC inhibitor,novel and potent

     AR-42 (OSU-HDAC42) Chemical Structure
  78. GC19037 ARS-853 ARS-853 is a selective, covalent KRASG12C inhibitor with an IC50 of 2.5 uM. ARS-853 Chemical Structure
  79. GC12070 Ascorbic acid (Standard)

    Ascorbate, NSC 33832, NSC 218455, Vitamin C

     An electron donor Ascorbic acid (Standard) Chemical Structure
  80. GN10702 Asiatic acid

    Dammarolic Acid, NSC 166063

     Asiatic acid Chemical Structure
  81. GN10534 Asiaticoside

    Ba 2742, NSC 36002, NSC 166062

     Asiaticoside Chemical Structure
  82. GC19041 ASK1-IN-1 ASK1-IN-1 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87 nM. ASK1-IN-1 Chemical Structure
  83. GN10561 astragalin

    Astragalin, Kaempferol 3-β-D-glucopyranoside

     astragalin Chemical Structure
  84. GC18109 Astragaloside A

    AS-A, AST-A, Astramembrannin I

     Astragaloside A is an active saponin compound extracted from Astragalus membranaceus with antioxidant, cardioprotective, anti-inflammatory, antiviral, antibacterial, antifibrosis, antidiabetic and immunomodulatory pharmacological effects. Astragaloside A Chemical Structure
  85. GC35415 Astramembrangenin Astramembrangenin Chemical Structure
  86. GC15870 AT7519 Multi-CDK inhibitor AT7519 Chemical Structure
  87. GC13998 AT7519 Hydrochloride A Cdk inhibitor AT7519 Hydrochloride Chemical Structure
  88. GC10638 AT9283 A broad spectrum kinase inhibitor AT9283 Chemical Structure
  89. GC18133 ATB-346

    ATB-346

     ATB-346 (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). ATB-346 Chemical Structure
  90. GN10394 Atractylenolide III

    Atractylenolide β, Codonolactone

     Atractylenolide III Chemical Structure
  91. GC13332 Aurora A Inhibitor I A potent and selective inhibitor of Aurora A kinase Aurora A Inhibitor I Chemical Structure
  92. GC15295 AUY922 (NVP-AUY922)

    VER-52296, AUY-922, AUY 922, Luminespib

     AUY922 (NVP-AUY922) is a potent and selective inhibitor of HSP90, effectively inhibiting both HSP90α and HSP90β with similar IC50 values of 13nM and 21nM, respectively. AUY922 (NVP-AUY922) Chemical Structure
  93. GC17045 AXL1717

    AXL 1717, NSC 36407, Picropodophyllin, PPP

     A potent and selective inhibitor of IGF-1R AXL1717 Chemical Structure
  94. GC15055 AZ 628

    AZ-628; AZ628

    Raf kinases,potent and ATP-competitive

     AZ 628 Chemical Structure
  95. GC13433 AZ 960 A JAK2 inhibitor AZ 960 Chemical Structure
  96. GC15033 Azathioprine

    Azamune, Azoran, BW 57322, Imuran, NSC 39084

     purine synthesis and GTP-binding protein Rac1 activation inhibitor Azathioprine Chemical Structure
  97. GC12660 AZD1208

    AZD 1208;AZD-1208

     AZD1208 is a potent, highly selective, and orally available Pim kinase inhibitor, with IC50 values of 0.4, 5, and 1.9nM for PIM1, PIM2, and PIM3, respectively. AZD1208 Chemical Structure
  98. GC13029 AZD2014

    AZD 2014; AZD-2014

     AZD2014 (AZD2014) is an ATP competitive mTOR inhibitor with an IC50 of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes. AZD2014 Chemical Structure
  99. GC16380 AZD8055

    CCG-168

    AZD8055 is a new ATP-competitive mTOR inhibitor with an IC50 of 0.8 nmol/L and a Ki of 1.3 nmol/L.

     AZD8055 Chemical Structure
  100. GC19054 Azoramide Azoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity. Azoramide Chemical Structure
  101. GC35458 Bacopaside II A triterpene glycoside Bacopaside II Chemical Structure

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