GLPBio

YUKA1

Catalog No.: GC37956Purity:>98%
COASDSData Sheet

YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity.

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YUKA1
Cas No.: 708991-09-7
10mM (in 1mL DMSO)In Stock
$267.00
1
5mgIn Stock
$243.00
1
10mgIn Stock
$387.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity[1]. IC50: 2.66 μM (KDM5A), 7.12 μM (KDM5C)[1]

[1]. Gale M, et al. Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. Oncotarget. 2016 Jun 28;7(26):39931-39944.

Chemical Properties

CAS No.
708991-09-7
SMILES
C=CCOC1=C(CNN2C(S)=NN=C2)C=CC=C1OC
Molecular Formula
C13H16N4O2S
Molecular Weight
292.36
Solubility
Soluble in DMSO
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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