GLPBio

DNA2 inhibitor C5

Catalog No.: GC38207Purity:>98.00%
COASDSData Sheet
DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress.

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DNA2 inhibitor C5
Cas No.: 35973-25-2
10mM (in 1mL DMSO)In Stock
$103.00
1
1mgIn Stock
$40.00
1
5mgIn Stock
$86.00
1
10mgIn Stock
$140.00
1
25mgIn Stock
$238.00
1
50mgIn Stock
$364.00
1
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Description

DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress[1].

[1]. Binghui Shen, et al. Dna2 inhibitors for cancer treatment. US20170226063A1.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
35973-25-2
SMILES
O=C(C1=C(O)C2=CC=CC([N+]([O-])=O)=C2N=C1)O
Molecular Formula
C10H6N2O5
Molecular Weight
234.17
Solubility
DMSO: 31.25 mg/mL (133.45 mM)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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