DM3-SMe |
| Catalog No.GC38355 |
DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 796073-70-6
Sample solution is provided at 25 µL, 10mM.
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DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].
[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). [2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-Science.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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