GLPBio

10β,17β-dihydroxyestra-1,4-dien-3-one

Catalog No.: GC38542Purity:>98.50%Synonyms: DHED
COASDSData Sheet
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain.

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10β,17β-dihydroxyestra-1,4-dien-3-one
Cas No.: 549-02-0
10mM (in 1mL DMSO)In Stock
$162.00
1
1mgIn Stock
$52.00
1
5mgIn Stock
$81.00
1
10mgIn Stock
$153.00
1
25mgIn Stock
$337.00
1
50mgIn Stock
$612.00
1
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Description

10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1].

10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is an inactive bioprecursor prodrug of 17β-estradiol converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes[1].

[1]. Merchenthaler I, et al. Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery. Sci Rep. 2016 Aug 1;6:30721.

Product Documents

Purity:>98.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
549-02-0
Synonyms
DHED
SMILES
C[C@@]12[C@@H](O)CC[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(O)[C@@]3([H])CC2)=O
Molecular Formula
C18H24O3
Molecular Weight
288.38
Solubility
DMSO: 250 mg/mL (866.91 mM)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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